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    Majin membrane anchored junction protein [ Mus musculus (house mouse) ]

    Gene ID: 622554, updated on 10-Dec-2024

    Summary

    Official Symbol
    Majinprovided by MGI
    Official Full Name
    membrane anchored junction proteinprovided by MGI
    Primary source
    MGI:MGI:1923913
    See related
    Ensembl:ENSMUSG00000024786 AllianceGenome:MGI:1923913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700123I01Rik
    Summary
    Predicted to enable DNA binding activity. Involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Acts upstream of or within double-strand break repair involved in meiotic recombination; oogenesis; and spermatogenesis. Located in chromosome, telomeric region and nuclear inner membrane. Is expressed in several structures, including gonad; liver; lung; muscle tissue; and spleen. Orthologous to human MAJIN (membrane anchored junction protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 2.9) and large intestine adult (RPKM 0.2) See more
    Orthologs
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    Genomic context

    See Majin in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6234358..6274349)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6184345..6224230)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5510 Neighboring gene basic leucine zipper transcription factor, ATF-like 2 Neighboring gene protein phosphatase 2, regulatory subunit B', beta Neighboring gene STARR-positive B cell enhancer ABC_E9990 Neighboring gene STARR-positive B cell enhancer ABC_E5681 Neighboring gene glycoprotein hormone alpha 2 Neighboring gene STARR-positive B cell enhancer ABC_E619 Neighboring gene autophagy related 2A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region PubMed 
    located_in nuclear envelope PubMed 
    is_active_in nuclear inner membrane  
    located_in nuclear inner membrane PubMed 
    located_in nuclear membrane PubMed 

    General protein information

    Preferred Names
    membrane-anchored junction protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165919.2NP_001159391.1  membrane-anchored junction protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC127556
      Consensus CDS
      CCDS50364.1
      UniProtKB/Swiss-Prot
      E9Q4N4, Q9D992
      UniProtKB/TrEMBL
      B2RQN5
      Related
      ENSMUSP00000109156.2, ENSMUST00000113528.2
      Conserved Domains (1) summary
      pfam15077
      Location:1240
      MAJIN; Membrane-anchored junction protein
    2. NM_001377074.1NP_001364003.1  membrane-anchored junction protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127556
      Conserved Domains (1) summary
      pfam15077
      Location:1182
      MAJIN; Membrane-anchored junction protein
    3. NM_001377075.1NP_001364004.1  membrane-anchored junction protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127556
      Related
      ENSMUSP00000025699.3, ENSMUST00000025699.9
      Conserved Domains (1) summary
      pfam15077
      Location:1108
      MAJIN; Membrane-anchored junction protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6234358..6274349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161650.1XP_036017543.1  membrane-anchored junction protein isoform X2

      Conserved Domains (1) summary
      pfam15077
      Location:1129
      MAJIN; Membrane-anchored junction protein
    2. XM_011248644.3XP_011246946.1  membrane-anchored junction protein isoform X1

      UniProtKB/TrEMBL
      B2RQN5
      Conserved Domains (1) summary
      pfam15077
      Location:14221
      MAJIN; Membrane-anchored junction protein
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