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    H2-M10.4 histocompatibility 2, M region locus 10.4 [ Mus musculus (house mouse) ]

    Gene ID: 224753, updated on 9-Dec-2024

    Summary

    Official Symbol
    H2-M10.4provided by MGI
    Official Full Name
    histocompatibility 2, M region locus 10.4provided by MGI
    Primary source
    MGI:MGI:1276527
    See related
    Ensembl:ENSMUSG00000048231 AllianceGenome:MGI:1276527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    15H
    Summary
    Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including bounding membrane of organelle; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-E (major histocompatibility complex, class I, E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See H2-M10.4 in Genome Data Viewer
    Location:
    17 B1; 17 19.09 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36769809..36773221, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36458917..36462329, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9, pseudogene 9 Neighboring gene oocyte specific homeobox 3, pseudogene 8 Neighboring gene histocompatibility 2, M region locus 9 pseudogene Neighboring gene histocompatibility 2, M region locus 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding  
    enables CD8 receptor binding  
    enables MHC class I protein binding  
    enables T cell receptor binding  
    enables TAP binding  
    enables TAP1 binding  
    enables TAP2 binding  
    enables beta-2-microglobulin binding  
    enables identical protein binding  
    enables natural killer cell lectin-like receptor binding  
    enables peptide antigen binding  
    enables peptide antigen binding  
    enables protein homodimerization activity  
    enables protein-folding chaperone binding  
    enables signaling receptor binding  
    enables signaling receptor binding  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi membrane  
    part_of MHC class I protein complex  
    part_of MHC class Ib protein complex  
    located_in cell surface  
    located_in cis-Golgi network membrane  
    located_in early endosome  
    located_in early endosome membrane  
    located_in endoplasmic reticulum  
    is_active_in external side of plasma membrane  
    is_active_in extracellular space  
    located_in lysosomal membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    histocompatibility 2, M region locus 10.4
    Names
    major histocompatibility complex class Ib M10.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177634.2 → NP_808302.1  histocompatibility 2, M region locus 10.4 precursor

      See identical proteins and their annotated locations for NP_808302.1

      Status: VALIDATED

      Source sequence(s)
      AC120403, AF539600, AY211081
      Consensus CDS
      CCDS28723.1
      UniProtKB/TrEMBL
      Q85ZW8, Q860W6
      Related
      ENSMUSP00000058686.8, ENSMUST00000057502.14
      Conserved Domains (2) summary
      cd07698
      Location:207 → 298
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:25 → 203
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      36769809..36773221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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