Rida reactive intermediate imine deaminase A homolog [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ridaprovided by MGI
Official Full Name: reactive intermediate imine deaminase A homologprovided by MGI
Primary source: MGI:MGI:1095401
See related: Ensembl:ENSMUSG00000022323 AllianceGenome:MGI:1095401
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HR12; HRP12; Hrsp12
Summary: Predicted to enable several functions, including 2-iminobutanoate deaminase activity; RNA endonuclease activity, producing 3'-phosphomonoesters; and identical protein binding activity. Predicted to be involved in negative regulation of epithelial cell proliferation and negative regulation of gene expression. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human RIDA (reactive intermediate imine deaminase A homolog). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 155.7), liver adult (RPKM 100.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 14.34 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (34484168..34495392, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (34484022..34495246, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hrsp12 (e-PCR), detects polymorphism
- UniSTS:143404

U50631 (e-PCR)
- UniSTS:125762

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-iminobutanoate deaminase activity	IEA Inferred from Electronic Annotation more info
enables 2-iminobutanoate deaminase activity	ISO Inferred from Sequence Orthology more info
enables 2-iminopropanoate deaminase activity	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity, producing 3'-phosphomonoesters	ISO Inferred from Sequence Orthology more info
enables RNA endonuclease activity, producing 3'-phosphomonoesters	ISS Inferred from Sequence or Structural Similarity more info
enables cation binding	ISO Inferred from Sequence Orthology more info
enables deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables transition metal ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 2-iminobutanoate/2-iminopropanoate deaminase

Names: heat-responsive protein 12; ribonuclease UK114; translation inhibitor L-PSP ribonuclease

NP_032313.2

EC 3.5.99.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.