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    H1f5 H1.5 linker histone, cluster member [ Mus musculus (house mouse) ]

    Gene ID: 56702, updated on 9-Dec-2024

    Summary

    Official Symbol
    H1f5provided by MGI
    Official Full Name
    H1.5 linker histone, cluster memberprovided by MGI
    Primary source
    MGI:MGI:1861461
    See related
    Ensembl:ENSMUSG00000058773 AllianceGenome:MGI:1861461
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H1B; H1-5; H1.5; H1s-3; Hist1h1b
    Summary
    Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Sep 2015]
    Orthologs
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    Genomic context

    See H1f5 in Genome Data Viewer
    Location:
    13 A3.1; 13 7.97 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21964002..21964795, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21779832..21780625, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene H2B clustered histone 15 Neighboring gene STARR-seq mESC enhancer starr_33863 Neighboring gene predicted gene 11274 Neighboring gene STARR-positive B cell enhancer ABC_E8510 Neighboring gene STARR-positive B cell enhancer ABC_E11533 Neighboring gene STARR-positive B cell enhancer ABC_E1456 Neighboring gene STARR-seq mESC enhancer starr_33864 Neighboring gene H3 clustered histone 11 Neighboring gene H2A clustered histone 22

    Genomic regions, transcripts, and products

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables chromatin DNA binding  
    enables chromatin DNA binding  
    enables double-stranded DNA binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables nucleosomal DNA binding  
    enables protein binding PubMed 
    enables structural constituent of chromatin  
    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromosome  
    located_in euchromatin  
    located_in heterochromatin  
    located_in heterochromatin  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    part_of nucleosome  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    histone H1.5
    Names
    H1 VAR.5
    H1 histone family, member 5
    histone 1, H1b
    histone 1, family 5
    histone cluster 1, H1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020034.2NP_064418.1  histone H1.5

      See identical proteins and their annotated locations for NP_064418.1

      Status: REVIEWED

      Source sequence(s)
      AL589651
      Consensus CDS
      CCDS26295.1
      UniProtKB/Swiss-Prot
      P43276, Q9CRM8
      UniProtKB/TrEMBL
      Q1WWK3
      Related
      ENSMUSP00000079356.3, ENSMUST00000080511.3
      Conserved Domains (1) summary
      pfam00538
      Location:38108
      Linker_histone; linker histone H1 and H5 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      21964002..21964795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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