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    Stac2 SH3 and cysteine rich domain 2 [ Mus musculus (house mouse) ]

    Gene ID: 217154, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Stac2provided by MGI
    Official Full Name
    SH3 and cysteine rich domain 2provided by MGI
    Primary source
    MGI:MGI:2144518
    See related
    Ensembl:ENSMUSG00000017400 AllianceGenome:MGI:2144518
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    24b2; 24b2/STAC2
    Summary
    Predicted to enable metal ion binding activity. Involved in positive regulation of protein localization to plasma membrane and positive regulation of voltage-gated calcium channel activity. Located in cytoplasmic side of plasma membrane. Is expressed in metanephros. Orthologous to human STAC2 (SH3 and cysteine rich domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 12.8), cortex adult (RPKM 11.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stac2 in Genome Data Viewer
    Location:
    11 D; 11 61.58 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97927449..97944288, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98036623..98053462, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10711 Neighboring gene STARR-positive B cell enhancer ABC_E5274 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97861691-97862052 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97864016-97864125 Neighboring gene STARR-positive B cell enhancer ABC_E11491 Neighboring gene ADP-ribosylation factor-like 5C Neighboring gene calcium channel, voltage-dependent, beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E3013 Neighboring gene ribosomal protein L19 Neighboring gene STARR-positive B cell enhancer ABC_E9372 Neighboring gene STARR-seq mESC enhancer starr_30655 Neighboring gene STARR-seq mESC enhancer starr_30656 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97944979-97945162 Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene mediator complex subunit 1 Neighboring gene ribosomal protein S6 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. STAC2 negatively regulates osteoclast formation by targeting the RANK signaling complex. Jeong E, et al. Cell Death Differ, 2018 Aug. PMID 29348675, Free PMC Article
    2. The histone methyltransferase ASH1L protects against bone loss by inhibiting osteoclastogenesis. Zhao X, et al. Cell Death Differ, 2024 May. PMID 38431690,
    3. stac1 and stac2 genes define discrete and distinct subsets of dorsal root ganglia neurons. Legha W, et al. Gene Expr Patterns, 2010 Oct-Dec. PMID 20736085
    4. Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of Ca(V)1.1. Polster A, et al. J Gen Physiol, 2018 Apr 2. PMID 29467163, Free PMC Article
    5. Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility. Nelson BR, et al. Proc Natl Acad Sci U S A, 2013 Jul 16. PMID 23818578, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38869

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH3 and cysteine-rich domain-containing protein 2
    Names
    SRC homology 3 and cysteine-rich domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146028.4 → NP_666140.1  SH3 and cysteine-rich domain-containing protein 2

      See identical proteins and their annotated locations for NP_666140.1

      Status: PROVISIONAL

      Source sequence(s)
      AL591209
      Consensus CDS
      CCDS25338.1
      UniProtKB/Swiss-Prot
      Q8BV93, Q8K2U4, Q8R1B0
      Related
      ENSMUSP00000017544.3, ENSMUST00000017544.9
      Conserved Domains (4) summary
      cd11985
      Location:293 → 345
      SH3_Stac2_C; C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 2 (Stac2)
      cd00029
      Location:111 → 161
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam16664
      Location:167 → 292
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
      cl17036
      Location:352 → 403
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97927449..97944288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245869.2 → XP_030101729.1  SH3 and cysteine-rich domain-containing protein 2 isoform X1

      Conserved Domains (3) summary
      cd11985
      Location:106 → 158
      SH3_Stac2_C; C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 2 (Stac2)
      pfam16664
      Location:3 → 105
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
      cl17036
      Location:165 → 216
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1B0.1 GenPept UniProtKB/Swiss-Prot:Q8R1B0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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