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    Tmem235 transmembrane protein 235 [ Mus musculus (house mouse) ]

    Gene ID: 546519, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem235provided by MGI
    Official Full Name
    transmembrane protein 235provided by MGI
    Primary source
    MGI:MGI:3651706
    See related
    Ensembl:ENSMUSG00000070330 AllianceGenome:MGI:3651706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cldn27; Gm12581
    Summary
    Located in apical plasma membrane and cytoplasm. Is expressed in several structures, including brain; gut; heart; liver; and metanephros. Orthologous to human TMEM235 (transmembrane protein 235). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 2.6) and duodenum adult (RPKM 0.1) See more
    Orthologs
    human all
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    Genomic context

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    See Tmem235 in Genome Data Viewer
    Location:
    11 E2; 11 82.96 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117751578..117756369)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117860752..117865543)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4020 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117693509-117693710 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117693767-117693876 Neighboring gene thymidine kinase 1 Neighboring gene arylformamidase Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117710178-117710379 Neighboring gene baculoviral IAP repeat-containing 5 Neighboring gene VISTA enhancer mm780 Neighboring gene STARR-positive B cell enhancer ABC_E5307 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117733294-117733546 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117733656-117733839 Neighboring gene predicted gene 11725 Neighboring gene threonine aldolase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117774097-117774206 Neighboring gene STARR-seq mESC enhancer starr_31285 Neighboring gene STARR-positive B cell enhancer ABC_E8474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117813554-117813821 Neighboring gene STARR-positive B cell enhancer ABC_E5308 Neighboring gene suppressor of cytokine signaling 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cataract-associated protein TMEM114, and TMEM235, are glycosylated transmembrane proteins that are distinct from claudin family members. Maher GJ, et al. FEBS Lett, 2011 Jul 21. PMID 21689651
    2. Predicted expansion of the claudin multigene family. Mineta K, et al. FEBS Lett, 2011 Feb 18. PMID 21276448
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 235
    Names
    claudin-27
    transmembrane protein ENSP00000364084 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085535.1 → NP_001079004.1  transmembrane protein 235 precursor

      See identical proteins and their annotated locations for NP_001079004.1

      Status: VALIDATED

      Source sequence(s)
      AL591433
      Consensus CDS
      CCDS36383.1
      UniProtKB/Swiss-Prot
      B1AQL3
      UniProtKB/TrEMBL
      A0A811BM33
      Related
      ENSMUSP00000091432.3, ENSMUST00000093905.3
      Conserved Domains (1) summary
      pfam13903
      Location:28 → 184
      Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      117751578..117756369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AQL3.3 GenPept UniProtKB/Swiss-Prot:B1AQL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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