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    Mmp11 matrix metallopeptidase 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25481, updated on 9-Dec-2024

    Summary

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    Symbol
    Mmp11provided by RGD
    Full Name
    matrix metallopeptidase 11provided by RGD
    Primary source
    RGD:3099
    See related
    EnsemblRapid:ENSRNOG00000028344 AllianceGenome:RGD:3099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ST3
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within basement membrane organization; collagen fibril organization; and negative regulation of fat cell differentiation. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human MMP11 (matrix metallopeptidase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 339.0), Kidney (RPKM 64.7) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mmp11 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12730284..12739067)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12730846..12739629)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13670051..13678834)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene V-set pre-B cell surrogate light chain 3 Neighboring gene similar to human chromosome 22 open reading frame 15 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit B1 Neighboring gene uncharacterized LOC134483889 Neighboring gene derlin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat stromelysin 3: cDNA cloning from healing skin wound, activation by furin and expression in rat tissues. Okada A, et al. Gene, 1997 Feb 7. PMID 9055814
    2. Matrix metalloproteinase-11/stromelysin-3 exhibits collagenolytic function against collagen VI under normal and malignant conditions. Motrescu ER, et al. Oncogene, 2008 Oct 23. PMID 18622425
    3. Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. Ng DC, et al. J Cell Biol, 2006 Jan 16. PMID 16401721, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within basement membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within collagen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stromelysin-3
    Names
    MMP-11
    Matrix metalloproteinase 11 (stromelysin 3)
    SL-3
    matrix metalloproteinase-11
    NP_037112.2
    XP_038954388.1
    XP_063135049.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012980.2 → NP_037112.2  stromelysin-3 precursor

      See identical proteins and their annotated locations for NP_037112.2

      Status: VALIDATED

      Source sequence(s)
      BC099781, BI291437, CK602095, U46034
      UniProtKB/Swiss-Prot
      P97568, Q499S5
      UniProtKB/TrEMBL
      A0A8L2R8J4, A6JKF2
      Related
      ENSRNOP00000035334.5, ENSRNOT00000031400.7
      Conserved Domains (2) summary
      cd00094
      Location:294 → 483
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:108 → 261
      Peptidase_M10; Matrixin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      12730284..12739067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098460.2 → XP_038954388.1  stromelysin-3 isoform X1

      Conserved Domains (2) summary
      cd00094
      Location:135 → 324
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:1 → 102
      Peptidase_M10; Matrixin

    2. XM_063278979.1 → XP_063135049.1  stromelysin-3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499S5.1 GenPept UniProtKB/Swiss-Prot:Q499S5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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