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    Rad23a RAD23 homolog A, nucleotide excision repair protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361381, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rad23aprovided by RGD
    Official Full Name
    RAD23 homolog A, nucleotide excision repair proteinprovided by RGD
    Primary source
    RGD:1309899
    See related
    EnsemblRapid:ENSRNOG00000003026 AllianceGenome:RGD:1309899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including enzyme binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of viral genome replication; and protein destabilization. Predicted to act upstream of or within DNA damage response. Predicted to be located in Golgi apparatus and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleoplasm. Orthologous to human RAD23A (RAD23 homolog A, nucleotide excision repair protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 292.7), Spleen (RPKM 265.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rad23a in Genome Data Viewer
    Location:
    19q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40219235..40225543)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23313563..23320702)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25949488..25956677, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene phenylalanyl-tRNA synthetase subunit alpha Neighboring gene GADD45G interacting protein 1 Neighboring gene calreticulin Neighboring gene uncharacterized LOC134483324 Neighboring gene DAN domain BMP antagonist family member 5 Neighboring gene uncharacterized LOC134483325 Neighboring gene nuclear factor I X

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains. Raasi S, et al. J Biol Chem, 2003 Mar 14. PMID 12643283
    2. Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. Sugasawa K, et al. Mol Cell Biol, 1997 Dec. PMID 9372924, Free PMC Article
    3. Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3. Laço MN, et al. PLoS One, 2012. PMID 22970133, Free PMC Article
    4. HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome. Li G, et al. PLoS One, 2010 Jun 29. PMID 20614012, Free PMC Article
    5. hHR23A is required to control the basal turnover of Chk1. Tan X, et al. Cell Signal, 2015 Nov. PMID 26296656

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UV excision repair protein RAD23 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013190.2 → NP_001013208.1  UV excision repair protein RAD23 homolog A isoform 1

      See identical proteins and their annotated locations for NP_001013208.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      F7FJT3, Q5XFX7
      Conserved Domains (4) summary
      cd01805
      Location:3 → 80
      RAD23_N; Ubiquitin-like domain of RAD23
      cd14377
      Location:162 → 201
      UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa
      TIGR00601
      Location:3 → 325
      rad23; UV excision repair protein Rad23
      pfam09280
      Location:231 → 286
      XPC-binding; XPC-binding domain

    2. NM_001399101.1 → NP_001386030.1  UV excision repair protein RAD23 homolog A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IY71, F7FJT3
      Conserved Domains (1) summary
      TIGR00601
      Location:3 → 361
      rad23; UV excision repair protein Rad23

    3. NM_001399102.1 → NP_001386031.1  UV excision repair protein RAD23 homolog A isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      F7FJT3
      Related
      ENSRNOP00000004042.6, ENSRNOT00000004042.7
      Conserved Domains (1) summary
      TIGR00601
      Location:3 → 360
      rad23; UV excision repair protein Rad23

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40219235..40225543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772411.4 → XP_008770633.1  UV excision repair protein RAD23 homolog A isoform X1

      UniProtKB/TrEMBL
      F7FJT3
      Conserved Domains (4) summary
      cd01805
      Location:3 → 80
      RAD23_N; Ubiquitin-like domain of RAD23
      smart00213
      Location:3 → 77
      UBQ; Ubiquitin homologues
      cd14377
      Location:162 → 201
      UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa
      pfam09280
      Location:232 → 287
      XPC-binding; XPC-binding domain

    RNA

    1. XR_010060012.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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