Pabpc6 poly(A) binding protein, cytoplasmic 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pabpc6provided by RGD
Official Full Name: poly(A) binding protein, cytoplasmic 6provided by RGD
Primary source: RGD:1311201
See related: EnsemblRapid:ENSRNOG00000017367 AllianceGenome:RGD:1311201
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pabpc3
Summary: Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Orthologous to human PABPC3 (poly(A) binding protein cytoplasmic 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: mouse all
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Genomic context

Location:: 1q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (53592902..53595978)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (51045264..51048340)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (51619875..51622951)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	ISO Inferred from Sequence Orthology more info
enables poly(U) RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: poly(A) binding protein, cytoplasmic 6

Names: poly(A) binding protein, cytoplasmic 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106208.2 → NP_001099678.1 poly(A) binding protein, cytoplasmic 6

See identical proteins and their annotated locations for NP_001099678.1

Status: VALIDATED

Source sequence(s)

BC168959

UniProtKB/TrEMBL

B5DF80, F7FIM0

Related

ENSRNOP00000023319.2, ENSRNOT00000023319.6

Conserved Domains (6) summary

TIGR01628
Location:11 → 622

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12378
Location:12 → 91

RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins

cd12379
Location:97 → 172

RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins

cd12380
Location:190 → 269

RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins

cd12381
Location:303 → 380

RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins

pfam00658
Location:555 → 621

PABP; Poly-adenylate binding protein, unique domain