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    Mri1 methylthioribose-1-phosphate isomerase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288912, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mri1provided by RGD
    Official Full Name
    methylthioribose-1-phosphate isomerase 1provided by RGD
    Primary source
    RGD:1307789
    See related
    EnsemblRapid:ENSRNOG00000026211 AllianceGenome:RGD:1307789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307789
    Summary
    Predicted to enable S-methyl-5-thioribose-1-phosphate isomerase activity and identical protein binding activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Orthologous to human MRI1 (methylthioribose-1-phosphate isomerase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 107.0), Adrenal (RPKM 98.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mri1 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40812114..40819846)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23907327..23913721)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25360299..25366283, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene ribonucleotide reductase regulatory subunit M2 like 1 Neighboring gene YJU2 splicing factor homolog B Neighboring gene similar to human chromosome 19 open reading frame 53 Neighboring gene zinc finger, SWIM-type containing 4 Neighboring gene microRNA 24-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
    2. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
    3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105780

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S-methyl-5-thioribose-1-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    methylthioribose-1-phosphate isomerase
    Names
    M1Pi
    MTR-1-P isomerase
    S-methyl-5-thioribose-1-phosphate isomerase
    methylthioribose-1-phosphate isomerase homolog
    translation initiation factor eIF-2B subunit alpha/beta/delta-like protein
    NP_001010947.1
    XP_063133899.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010947.2 → NP_001010947.1  methylthioribose-1-phosphate isomerase

      See identical proteins and their annotated locations for NP_001010947.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q5HZE4
      UniProtKB/TrEMBL
      A6IY99
      Related
      ENSRNOP00000003762.4, ENSRNOT00000003762.8
      Conserved Domains (2) summary
      TIGR00512
      Location:4 → 346
      salvage_mtnA; S-methyl-5-thioribose-1-phosphate isomerase
      pfam01008
      Location:44 → 346
      IF-2B; Initiation factor 2 subunit family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40812114..40819846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277829.1 → XP_063133899.1  methylthioribose-1-phosphate isomerase isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZE4.1 GenPept UniProtKB/Swiss-Prot:Q5HZE4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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