Otop1 otopetrin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Otop1provided by RGD
Official Full Name: otopetrin 1provided by RGD
Primary source: RGD:631389
See related: EnsemblRapid:ENSRNOG00000028423 AllianceGenome:RGD:631389
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and proton channel activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; negative regulation of type II interferon-mediated signaling pathway; and proton transmembrane transport. Predicted to act upstream of or within detection of gravity. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human OTOP1 (otopetrin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 52.1), Thymus (RPKM 49.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (76717330..76744785, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (72505036..72532497, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (77236278..77263729, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D14Rat29 (e-PCR), detects polymorphism
- UniSTS:118370

D14Rat39 (e-PCR), detects polymorphism
- UniSTS:118379

AU025609 (e-PCR)
- UniSTS:115093

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables proton channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables proton channel activity	ISO Inferred from Sequence Orthology more info
enables proton channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within detection of gravity	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proton channel OTOP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.