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    Mgmt O-6-methylguanine-DNA methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25332, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mgmtprovided by RGD
    Official Full Name
    O-6-methylguanine-DNA methyltransferaseprovided by RGD
    Primary source
    RGD:3087
    See related
    EnsemblRapid:ENSRNOG00000016038 AllianceGenome:RGD:3087
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium ion binding activity and methylated-DNA-[protein]-cysteine S-methyltransferase activity. Involved in several processes, including DNA alkylation repair; cellular response to ionizing radiation; and mammary gland epithelial cell differentiation. Predicted to be located in membrane. Predicted to be active in nucleoplasm. Biomarker of colon adenocarcinoma and melanoma. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; high grade glioma (multiple); and retinoblastoma. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 160.5), Spleen (RPKM 119.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mgmt in Genome Data Viewer
    Location:
    1q41
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (201140832..201367481)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (191710980..191937760)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (209237255..209464189)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485188 Neighboring gene cilia- and flagella-associated protein 251-like Neighboring gene uncharacterized LOC102552565 Neighboring gene EBF transcription factor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA alkylation repair PubMed 
    acts_upstream_of_or_within DNA alkylation repair  
    involved_in DNA damage response PubMed 
    acts_upstream_of_or_within DNA damage response  
    involved_in DNA repair  
    involved_in DNA repair  
    acts_upstream_of_or_within DNA repair  
    involved_in cellular response to ionizing radiation PubMed 
    involved_in cellular response to organic cyclic compound PubMed 
    involved_in cellular response to oxidative stress PubMed 
    involved_in mammary gland epithelial cell differentiation PubMed 
    involved_in methylation  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in positive regulation of DNA repair PubMed 
    involved_in positive regulation of double-strand break repair  
    involved_in positive regulation of double-strand break repair  
    involved_in response to ethanol PubMed 
    involved_in response to folic acid PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to toxic substance PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    Component Evidence Code Pubs
    located_in membrane  
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    methylated-DNA--protein-cysteine methyltransferase
    Names
    0-6-methylguanine-DNA methyltransferase
    6-O-methylguanine-DNA methyltransferase
    O(6)-alkylguanine-DNA alkyltransferase
    O-6-methylguanine-DNA-alkyltransferase
    O6-alkylguanine-DNA alkyltransferase
    O6-methylguanine-DNA methyltranferase
    NP_036993.1
    XP_038957518.1
    XP_063137786.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012861.1NP_036993.1  methylated-DNA--protein-cysteine methyltransferase

      See identical proteins and their annotated locations for NP_036993.1

      Status: PROVISIONAL

      Source sequence(s)
      S61804
      UniProtKB/Swiss-Prot
      P24528
      UniProtKB/TrEMBL
      A0A8L2QAS3, A6HX75
      Related
      ENSRNOP00000079311.1, ENSRNOT00000119456.2
      Conserved Domains (3) summary
      COG0350
      Location:6178
      AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
      TIGR00589
      Location:97177
      ogt; O-6-methylguanine DNA methyltransferase
      pfam02870
      Location:694
      Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      201140832..201367481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281716.1XP_063137786.1  methylated-DNA--protein-cysteine methyltransferase isoform X2

    2. XM_039101590.2XP_038957518.1  methylated-DNA--protein-cysteine methyltransferase isoform X1

      Conserved Domains (2) summary
      TIGR00589
      Location:58138
      ogt; O-6-methylguanine DNA methyltransferase
      pfam02870
      Location:555
      Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
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