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    Mnt MAX network transcriptional repressor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mntprovided by RGD
    Official Full Name
    MAX network transcriptional repressorprovided by RGD
    Primary source
    RGD:1308683
    See related
    EnsemblRapid:ENSRNOG00000002894 AllianceGenome:RGD:1308683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including cellular senescence; negative regulation of apoptotic signaling pathway; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Orthologous to human MNT (MAX network transcriptional repressor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 18.8), Spleen (RPKM 18.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mnt in Genome Data Viewer
    Location:
    10q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60197654..60213221)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (59699208..59714848)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (61683776..61700504)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene methyltransferase 16, RNA N6-adenosine Neighboring gene small G protein signaling modulator 2 Neighboring gene small nucleolar RNA SNORD91 family Neighboring gene TSR1, ribosome maturation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A repressor protein, Mnt, is a novel negative regulator of vascular smooth muscle cell hypertrophy by angiotensin II and neointimal hyperplasia by arterial injury. Takayanagi T, et al. Atherosclerosis, 2013 May. PMID 23535568, Free PMC Article
    2. Mnt transcriptional repressor is functionally regulated during cell cycle progression. Popov N, et al. Oncogene, 2005 Dec 15. PMID 16103876
    3. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. Meroni G, et al. EMBO J, 1997 May 15. PMID 9184233, Free PMC Article
    4. Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. Hurlin PJ, et al. EMBO J, 2003 Sep 15. PMID 12970171, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data identify Mnt as a previously unrecognized negative regulator of pathological vascular remodeling.
      Title: A repressor protein, Mnt, is a novel negative regulator of vascular smooth muscle cell hypertrophy by angiotensin II and neointimal hyperplasia by arterial injury.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    max-binding protein MNT
    Names
    MNT, MAX dimerization protein
    max binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105807.2 → NP_001099277.2  max-binding protein MNT

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0U1RRY7
      Related
      ENSRNOP00000075865.1, ENSRNOT00000092606.3
      Conserved Domains (1) summary
      cd11402
      Location:222 → 298
      bHLHzip_Mnt; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      60197654..60213221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085506.2 → XP_038941434.1  max-binding protein MNT isoform X1

      UniProtKB/TrEMBL
      D3ZF98
      Related
      ENSRNOP00000003933.5, ENSRNOT00000003933.7
      Conserved Domains (1) summary
      cd11402
      Location:221 → 284
      bHLHzip_Mnt; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins

    2. XM_039085507.2 → XP_038941435.1  max-binding protein MNT isoform X2

      Conserved Domains (1) summary
      cl00081
      Location:9 → 36
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    3. XM_039085508.2 → XP_038941436.1  max-binding protein MNT isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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