Eqtn equatorin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eqtnprovided by RGD
Official Full Name: equatorinprovided by RGD
Primary source: RGD:1563332
See related: EnsemblRapid:ENSRNOG00000026323 AllianceGenome:RGD:1563332
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Afaf
Summary: Predicted to be involved in acrosomal vesicle exocytosis; endocytosis; and fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to act upstream of or within establishment of localization in cell. Predicted to be located in early endosome and nucleus. Predicted to be active in inner acrosomal membrane; outer acrosomal membrane; and plasma membrane. Orthologous to human EQTN (equatorin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 75.3), Testes (RPKM 30.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (114851981..114880683, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (109734495..109762048, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (113852191..113881142, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Afaf expressed abundantly in the round spermatids, localized in the inner and outer membrane of forming acrosome, and declined in the maturing acrosomes.
Title: Afaf, a novel vesicle membrane protein, is related to acrosome formation in murine testis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in acrosomal vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in acrosomal vesicle exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within acrosomal vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fusion of sperm to egg plasma membrane involved in single fertilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in inner acrosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in inner acrosomal membrane	ISO Inferred from Sequence Orthology more info
located_in inner acrosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in outer acrosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in outer acrosomal membrane	ISO Inferred from Sequence Orthology more info
located_in outer acrosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: equatorin

Names: Acrosome formation associated factor; acrosome formation-associated factor; equatorin, sperm acrosome associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039345.1 → NP_001034434.1 equatorin precursor

See identical proteins and their annotated locations for NP_001034434.1

Status: PROVISIONAL

Source sequence(s)

DQ336136

UniProtKB/Swiss-Prot

F1LP31, Q2LCV6

Related

ENSRNOP00000105087.1, ENSRNOT00000169883.1

Conserved Domains (1) summary

pfam15339
Location:63 → 245

Afaf; Acrosome formation-associated factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

114851981..114880683 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110577.2 → XP_038966505.1 equatorin isoform X1

UniProtKB/Swiss-Prot

F1LP31, Q2LCV6

UniProtKB/TrEMBL

A0A8L2QIL8

Related

ENSRNOP00000034172.5, ENSRNOT00000029441.8

Conserved Domains (1) summary

pfam15339
Location:63 → 250

Afaf; Acrosome formation-associated factor