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    Exd1 exonuclease 3'-5' domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311334, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Exd1provided by RGD
    Official Full Name
    exonuclease 3'-5' domain containing 1provided by RGD
    Primary source
    RGD:1561009
    See related
    EnsemblRapid:ENSRNOG00000025360 AllianceGenome:RGD:1561009
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Exdl1; RGD1561009
    Summary
    Predicted to enable 3'-5' exonuclease activity and nucleic acid binding activity. Predicted to be involved in piRNA processing. Predicted to be part of PET complex. Orthologous to human EXD1 (exonuclease 3'-5' domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 19.9), Kidney (RPKM 1.8) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Exd1 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (126961800..126989738, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106507839..106535922, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111326388..111354419, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene developmental pluripotency-associated protein 3 Neighboring gene SH3 domain-binding protein 5-like Neighboring gene calcineurin-like EF-hand protein 1 Neighboring gene OIP5 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway. Yang Z, et al. Mol Cell, 2016 Jan 7. PMID 26669262, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of PET complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PET complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    piRNA biogenesis protein EXD1
    Names
    exonuclease 3'-5' domain-containing protein 1
    exonuclease 3'-5' domain-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107761.2 → NP_001101231.1  piRNA biogenesis protein EXD1

      See identical proteins and their annotated locations for NP_001101231.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HPF6, D4AD21
      Related
      ENSRNOP00000038378.2, ENSRNOT00000038365.4
      Conserved Domains (1) summary
      cd06148
      Location:146 → 344
      Egl_like_exo; DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins

    2. NM_001433379.1 → NP_001420308.1  piRNA biogenesis protein EXD1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HPF6, D4AD21

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      126961800..126989738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234766.5 → XP_006234828.1  piRNA biogenesis protein EXD1 isoform X1

      Related
      ENSRNOP00000109799.1, ENSRNOT00000166520.1
      Conserved Domains (1) summary
      cd06148
      Location:146 → 344
      Egl_like_exo; DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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