Gpr156 G protein-coupled receptor 156 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Gpr156provided by RGD
Full Name: G protein-coupled receptor 156provided by RGD
Primary source: RGD:708438
See related: EnsemblRapid:ENSRNOG00000002797 AllianceGenome:RGD:708438
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gababl
Summary: Predicted to enable G protein-coupled GABA receptor activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway and stereocilium bundle organization. Predicted to be located in plasma membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human GPR156 (G protein-coupled receptor 156). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1.3), Adrenal (RPKM 1.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (76228104..76320890, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (62722632..62815402, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (65285468..65350442, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GABAB receptor cell surface stability is modulated by phosphorylation and chronic agonist treatment
Title: Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability.

Submit: New GeneRIF Correction

General gene information

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Markers

BQ204693 (e-PCR)
- UniSTS:261190

D11Rat4 (e-PCR)
- UniSTS:118252

BE115109 (e-PCR)
- UniSTS:261369

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled GABA receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled GABA receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in stereocilium bundle organization	ISO Inferred from Sequence Orthology more info
involved_in stereocilium bundle organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of G protein-coupled receptor heterodimeric complex	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable G-protein coupled receptor 156

Names: GABAB-related G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153295.2 → NP_695207.2 probable G-protein coupled receptor 156

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q8K451

UniProtKB/TrEMBL

A6IR84, G3V6C5

Related

ENSRNOP00000003773.1, ENSRNOT00000003773.4

Conserved Domains (1) summary

cd15292
Location:48 → 317

7tmC_GPR156; orphan GPR156, member of the class C family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

76228104..76320890 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088048.2 → XP_038943976.1 probable G-protein coupled receptor 156 isoform X1

UniProtKB/Swiss-Prot

Q8K451

Conserved Domains (2) summary

cd14964
Location:60 → 81

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:50 → 292

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily