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    Spns3 SPNS lysolipid transporter 3, sphingosine-1-phosphate [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spns3provided by RGD
    Official Full Name
    SPNS lysolipid transporter 3, sphingosine-1-phosphateprovided by RGD
    Primary source
    RGD:1561884
    See related
    EnsemblRapid:ENSRNOG00000015873 AllianceGenome:RGD:1561884
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561884
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Orthologous to human SPNS3 (SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 23.5), Thymus (RPKM 12.8) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spns3 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (57612796..57667601, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57114247..57169056, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59056460..59113310, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene MYB binding protein 1a Neighboring gene SPNS lysolipid transporter 2, sphingosine-1-phosphate Neighboring gene uncharacterized LOC134480821 Neighboring gene ubiquitin-conjugating enzyme E2G 1 Neighboring gene small nuclear ribonucleoprotein G-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein spinster homolog 3
    Names
    SPNS sphingolipid transporter 3
    sphingolipid transporter 3
    spinster homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109035.1 → NP_001102505.1  protein spinster homolog 3

      See identical proteins and their annotated locations for NP_001102505.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HGG1, D3ZCZ0
      Related
      ENSRNOP00000050332.2, ENSRNOT00000041886.4
      Conserved Domains (2) summary
      cd06174
      Location:67 → 448
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:67 → 396
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      57612796..57667601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767857.4 → XP_008766079.1  protein spinster homolog 3 isoform X2

      Conserved Domains (2) summary
      cd06174
      Location:53 → 470
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:55 → 418
      MFS_1; Major Facilitator Superfamily

    2. XM_063269633.1 → XP_063125703.1  protein spinster homolog 3 isoform X3

    3. XM_006246786.5 → XP_006246848.1  protein spinster homolog 3 isoform X1

      See identical proteins and their annotated locations for XP_006246848.1

      UniProtKB/TrEMBL
      A0A8I5ZPL7, A6HGG2
      Related
      ENSRNOP00000080396.1, ENSRNOT00000110777.2
      Conserved Domains (2) summary
      cd06174
      Location:53 → 470
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:55 → 418
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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