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    Chrdl2 chordin-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308854, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chrdl2provided by RGD
    Official Full Name
    chordin-like 2provided by RGD
    Primary source
    RGD:1306179
    See related
    EnsemblRapid:ENSRNOG00000018394 AllianceGenome:RGD:1306179
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable BMP binding activity. Predicted to be involved in cell differentiation and negative regulation of BMP signaling pathway. Predicted to act upstream of or within chondrocyte differentiation. Predicted to be located in extracellular region. Orthologous to human CHRDL2 (chordin like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 14.3), Muscle (RPKM 7.7) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Chrdl2 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (163755316..163782758)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154343201..154370651)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165008997..165036431)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 169 Neighboring gene small nucleolar RNA SNORA20 Neighboring gene Set nuclear proto-oncogene, pseudogene 4 Neighboring gene ribosomal protein L23,pseudogene 3 Neighboring gene DNA polymerase delta 3, accessory subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables BMP binding  
    Component Evidence Code Pubs
    located_in extracellular region  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107537.1NP_001101007.1  chordin-like protein 2 precursor

      See identical proteins and their annotated locations for NP_001101007.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A0A8I6AAN2, A6I6L1, F1LW58
      Related
      ENSRNOP00000024803.7, ENSRNOT00000024803.9
      Conserved Domains (2) summary
      pfam00093
      Location:251313
      VWC; von Willebrand factor type C domain
      cl17735
      Location:3395
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      163755316..163782758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113275.2XP_038969203.1  chordin-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A6I6L3
      Conserved Domains (2) summary
      pfam00093
      Location:166228
      VWC; von Willebrand factor type C domain
      cl17735
      Location:2689
      VWC; von Willebrand factor type C domain
    2. XM_039113276.2XP_038969204.1  chordin-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A6I6L3
      Conserved Domains (2) summary
      pfam00093
      Location:166228
      VWC; von Willebrand factor type C domain
      cl17735
      Location:2689
      VWC; von Willebrand factor type C domain
    3. XM_017589185.3XP_017444674.2  chordin-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAN2
      Conserved Domains (1) summary
      cl17735
      Location:198260
      VWC; von Willebrand factor type C domain
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