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    Zdhhc6 zinc finger DHHC-type palmitoyltransferase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361771, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zdhhc6provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 6provided by RGD
    Primary source
    RGD:1304657
    See related
    EnsemblRapid:ENSRNOG00000036576 AllianceGenome:RGD:1304657
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity and protein-cysteine S-stearoyltransferase activity. Predicted to be involved in positive regulation of mitochondrial fusion; protein lipidation; and protein targeting to membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 223.9), Kidney (RPKM 156.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zdhhc6 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (264340883..264361435, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (254335472..254356141, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (276291411..276309633, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene extensin-like Neighboring gene glycerol-3-phosphate acyltransferase, mitochondrial Neighboring gene tectorin beta Neighboring gene guanylate cyclase 2G Neighboring gene acyl-CoA synthetase long-chain family member 5 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene uncharacterized LOC134485256 Neighboring gene uncharacterized LOC134485255

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase. Fairbank M, et al. FEBS Lett, 2012 Jul 30. PMID 22728137
    2. Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade. Abrami L, et al. Elife, 2017 Aug 15. PMID 28826475, Free PMC Article
    3. Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals. Gorleku OA, et al. J Biol Chem, 2011 Nov 11. PMID 21926431, Free PMC Article
    4. Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. Fredericks GJ, et al. Proc Natl Acad Sci U S A, 2014 Nov 18. PMID 25368151, Free PMC Article
    5. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Senyilmaz D, et al. Nature, 2015 Sep 3. PMID 26214738, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125041

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-stearoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stearoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC6
    Names
    membrane-associated DHHC6 zinc finger protein
    probable palmitoyltransferase ZDHHC6
    zinc finger, DHHC domain containing 6
    zinc finger, DHHC-type containing 6
    NP_001032741.1
    XP_038940605.1
    XP_038940607.1
    XP_038940608.1
    XP_063124828.1
    XP_063124843.1
    XP_063124846.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037652.1 → NP_001032741.1  palmitoyltransferase ZDHHC6

      See identical proteins and their annotated locations for NP_001032741.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107928
      UniProtKB/TrEMBL
      A0A8I5ZNT0, F1LQB4, Q32PY5
      Related
      ENSRNOP00000051566.5, ENSRNOT00000054681.6
      Conserved Domains (2) summary
      pfam01529
      Location:95 → 241
      DHHC; DHHC palmitoyltransferase
      pfam07653
      Location:317 → 394
      SH3_2; Variant SH3 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      264340883..264361435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084677.2 → XP_038940605.1  palmitoyltransferase ZDHHC6 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7F3, A6JHZ3
      Related
      ENSRNOP00000080065.2, ENSRNOT00000103424.2
      Conserved Domains (1) summary
      pfam01529
      Location:95 → 241
      DHHC; DHHC palmitoyltransferase

    2. XM_063268773.1 → XP_063124843.1  palmitoyltransferase ZDHHC6 isoform X5

      UniProtKB/TrEMBL
      A6JHZ3

    3. XM_039084680.2 → XP_038940608.1  palmitoyltransferase ZDHHC6 isoform X4

      UniProtKB/TrEMBL
      A6JHZ3
      Related
      ENSRNOP00000111812.1, ENSRNOT00000121139.1
      Conserved Domains (1) summary
      pfam01529
      Location:95 → 241
      DHHC; DHHC palmitoyltransferase

    4. XM_063268758.1 → XP_063124828.1  palmitoyltransferase ZDHHC6 isoform X1

      UniProtKB/TrEMBL
      F1LQB4

    5. XM_039084679.2 → XP_038940607.1  palmitoyltransferase ZDHHC6 isoform X3

      UniProtKB/TrEMBL
      A6JHZ3
      Related
      ENSRNOP00000106692.1, ENSRNOT00000131371.1
      Conserved Domains (1) summary
      pfam01529
      Location:95 → 241
      DHHC; DHHC palmitoyltransferase

    6. XM_063268776.1 → XP_063124846.1  palmitoyltransferase ZDHHC6 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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