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    Med26 mediator complex subunit 26 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306328, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Med26provided by RGD
    Official Full Name
    mediator complex subunit 26provided by RGD
    Primary source
    RGD:1309524
    See related
    EnsemblRapid:ENSRNOG00000012270 AllianceGenome:RGD:1309524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Slc35e1
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of gene expression and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED26 (mediator complex subunit 26). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: GeneID 306328 was annotated as 'solute carrier family 35, member E1 (predicted)' by Celera, but this locus actually encodes mediator complex subunit 26. GeneID: 498599 encodes solute carrier family 35, member E1. [10 Jan 2008]
    Expression
    Biased expression in Testes (RPKM 44.2), Thymus (RPKM 36.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Med26 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17333770..17384797)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17299722..17350168)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19001061..19050874)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097450 Neighboring gene small integral membrane protein 7 Neighboring gene uncharacterized LOC134482462 Neighboring gene solute carrier family 35, member E1 Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene similar to human chromosome 19 open reading frame 44

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article
    2. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Zhang X, et al. Mol Cell, 2005 Jul 1. PMID 15989967
    3. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 26
    Names
    solute carrier family 35, member E1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107300.4 → NP_001100770.2  mediator of RNA polymerase II transcription subunit 26

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2JW54
      Related
      ENSRNOP00000109189.1, ENSRNOT00000146426.1
      Conserved Domains (3) summary
      smart00509
      Location:12 → 86
      TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
      pfam15693
      Location:407 → 586
      Med26_C; Mediator complex subunit 26 C-terminal
      pfam15694
      Location:178 → 405
      Med26_M; Mediator complex subunit 26 middle domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      17333770..17384797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094478.2 → XP_038950406.1  mediator of RNA polymerase II transcription subunit 26 isoform X1

      Conserved Domains (3) summary
      smart00509
      Location:47 → 107
      TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
      pfam15693
      Location:428 → 607
      Med26_C; Mediator complex subunit 26 C-terminal
      pfam15694
      Location:199 → 426
      Med26_M; Mediator complex subunit 26 middle domain

    2. XM_039094481.2 → XP_038950409.1  mediator of RNA polymerase II transcription subunit 26 isoform X3

      UniProtKB/TrEMBL
      A6K9N9
      Conserved Domains (3) summary
      smart00509
      Location:1 → 59
      TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
      pfam15693
      Location:380 → 559
      Med26_C; Mediator complex subunit 26 C-terminal
      pfam15694
      Location:151 → 378
      Med26_M; Mediator complex subunit 26 middle domain

    3. XM_063275371.1 → XP_063131441.1  mediator of RNA polymerase II transcription subunit 26 isoform X3

      UniProtKB/TrEMBL
      A6K9N9
      Related
      ENSRNOP00000111891.1, ENSRNOT00000121997.1

    4. XM_006252800.5 → XP_006252862.1  mediator of RNA polymerase II transcription subunit 26 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JW54
      Related
      ENSRNOP00000101524.1, ENSRNOT00000158731.1
      Conserved Domains (3) summary
      smart00509
      Location:16 → 76
      TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
      pfam15693
      Location:397 → 576
      Med26_C; Mediator complex subunit 26 C-terminal
      pfam15694
      Location:168 → 395
      Med26_M; Mediator complex subunit 26 middle domain

    5. XM_039094480.2 → XP_038950408.1  mediator of RNA polymerase II transcription subunit 26 isoform X3

      UniProtKB/TrEMBL
      A6K9N9
      Conserved Domains (3) summary
      smart00509
      Location:1 → 59
      TFS2N; Domain in the N-terminus of transcription elongation factor S-II (and elsewhere)
      pfam15693
      Location:380 → 559
      Med26_C; Mediator complex subunit 26 C-terminal
      pfam15694
      Location:151 → 378
      Med26_M; Mediator complex subunit 26 middle domain
    Nucleotide Protein Strain
    Heading Accession and Version

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