U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Abcd3 ATP binding cassette subfamily D member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25270, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abcd3provided by RGD
    Official Full Name
    ATP binding cassette subfamily D member 3provided by RGD
    Primary source
    RGD:2007
    See related
    EnsemblRapid:ENSRNOG00000011929 AllianceGenome:RGD:2007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PMP70; Pxmp1
    Summary
    Enables ATP binding activity and identical protein binding activity. Involved in response to organic cyclic compound and response to xenobiotic stimulus. Located in mitochondrion and peroxisomal membrane. Human ortholog(s) of this gene implicated in Zellweger syndrome and congenital bile acid synthesis defect 5. Orthologous to human ABCD3 (ATP binding cassette subfamily D member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 786.7), Kidney (RPKM 682.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Abcd3 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (212536791..212590379, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (209852087..209905763, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (225335708..225389120, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555482 Neighboring gene uncharacterized LOC134485958 Neighboring gene coagulation factor III, tissue factor Neighboring gene uncharacterized LOC108350099 Neighboring gene uncharacterized LOC108350100

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity  
    enables ATP binding  
    enables ATP binding PubMed 
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATPase-coupled transmembrane transporter activity  
    enables ATPase-coupled transmembrane transporter activity  
    enables ATPase-coupled transmembrane transporter activity PubMed 
    enables fatty acyl-CoA hydrolase activity  
    enables fatty acyl-CoA hydrolase activity  
    enables identical protein binding PubMed 
    enables long-chain fatty acid transmembrane transporter activity  
    enables long-chain fatty acid transmembrane transporter activity  
    enables long-chain fatty acid transmembrane transporter activity  
    enables long-chain fatty acid transmembrane transporter activity  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport  
    involved_in bile acid and bile salt transport  
    involved_in bile acid biosynthetic process  
    involved_in bile acid biosynthetic process  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid beta-oxidation  
    involved_in fatty acid biosynthetic process  
    involved_in fatty acid biosynthetic process  
    involved_in lipid transport  
    involved_in long-chain fatty acid import into peroxisome  
    involved_in long-chain fatty acid import into peroxisome  
    involved_in long-chain fatty acid import into peroxisome  
    involved_in long-chain fatty acid import into peroxisome  
    involved_in long-chain fatty acid import into peroxisome PubMed 
    involved_in peroxisome organization  
    involved_in peroxisome organization  
    involved_in phytanic acid metabolic process  
    involved_in phytanic acid metabolic process  
    involved_in response to organic cyclic compound PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in transmembrane transport  
    involved_in very long-chain fatty acid catabolic process  
    involved_in very long-chain fatty acid catabolic process  
    involved_in very long-chain fatty acid metabolic process  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle  
    located_in membrane  
    located_in mitochondrion PubMed 
    located_in peroxisomal matrix  
    is_active_in peroxisomal membrane  
    located_in peroxisomal membrane PubMed 
    located_in peroxisomal membrane  
    located_in peroxisomal membrane  
    located_in peroxisome PubMed 
    located_in peroxisome  
    located_in peroxisome PubMed 

    General protein information

    Preferred Names
    ATP-binding cassette sub-family D member 3
    Names
    70-kDa peroxisomal membrane protein
    ATP-binding cassette, sub-family D (ALD), member 3
    ATP-binding cassette, subfamily D (ALD), member 3
    Peroxisomal membrane protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012804.3NP_036936.1  ATP-binding cassette sub-family D member 3

      See identical proteins and their annotated locations for NP_036936.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P16970
      UniProtKB/TrEMBL
      A0A8I6ANP9
      Related
      ENSRNOP00000016739.5, ENSRNOT00000016739.8
      Conserved Domains (1) summary
      TIGR00954
      Location:1647
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      212536791..212590379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101774.2XP_038957702.1  ATP-binding cassette sub-family D member 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A495, A0A8I6ANP9
      Related
      ENSRNOP00000085866.1, ENSRNOT00000106914.2
      Conserved Domains (1) summary
      TIGR00954
      Location:3612
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
    2. XM_039101772.2XP_038957700.1  ATP-binding cassette sub-family D member 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN14, A0A8I6ANP9
      Related
      ENSRNOP00000079442.2, ENSRNOT00000119497.2
      Conserved Domains (1) summary
      TIGR00954
      Location:1647
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
    3. XM_063281326.1XP_063137396.1  ATP-binding cassette sub-family D member 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A495, A0A8I6ANP9
    External link. Please review our privacy policy.