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    Efcab11 EF-hand calcium binding domain 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500705, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Efcab11provided by RGD
    Official Full Name
    EF-hand calcium binding domain 11provided by RGD
    Primary source
    RGD:1565006
    See related
    EnsemblRapid:ENSRNOG00000053317 AllianceGenome:RGD:1565006
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity. Orthologous to human EFCAB11 (EF-hand calcium binding domain 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 12.1), Thymus (RPKM 3.8) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Efcab11 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (124738531..124892623, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (119008908..119162994, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (123742971..123894714, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene forkhead box N3 Neighboring gene uncharacterized LOC102550560 Neighboring gene uncharacterized LOC108351290 Neighboring gene uncharacterized LOC120103598 Neighboring gene tyrosyl-DNA phosphodiesterase 1 Neighboring gene potassium two pore domain channel subfamily K member 13 Neighboring gene uncharacterized LOC120103599

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel candidate genes for impaired nephron development in a rat model with inherited nephron deficit and albuminuria. Herlan L, et al. Clin Exp Pharmacol Physiol, 2015 Oct. PMID 26192016
    2. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand calcium-binding domain-containing protein 11
    Names
    EF-hand domain-containing protein C14orf143 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024350.1 → NP_001019521.1  EF-hand calcium-binding domain-containing protein 11

      See identical proteins and their annotated locations for NP_001019521.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079408
      UniProtKB/Swiss-Prot
      Q6AXQ2
      UniProtKB/TrEMBL
      A6JEG2, A6JEG3
      Related
      ENSRNOP00000069648.1, ENSRNOT00000082444.3
      Conserved Domains (3) summary
      cd00051
      Location:95 → 152
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:96 → 156
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:25 → 84
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      124738531..124892623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112741.1 → XP_038968669.1  EF-hand calcium-binding domain-containing protein 11 isoform X1

      Conserved Domains (1) summary
      COG5126
      Location:3 → 104
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. XM_039112742.2 → XP_038968670.1  EF-hand calcium-binding domain-containing protein 11 isoform X1

      Conserved Domains (1) summary
      COG5126
      Location:3 → 104
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    3. XM_039112743.2 → XP_038968671.1  EF-hand calcium-binding domain-containing protein 11 isoform X2

      Conserved Domains (1) summary
      pfam13499
      Location:30 → 93
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXQ2.1 GenPept UniProtKB/Swiss-Prot:Q6AXQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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