Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp2r1provided by RGD
Official Full Name: cytochrome P450, family 2, subfamily r, polypeptide 1provided by RGD
Primary source: RGD:1311866
See related: EnsemblRapid:ENSRNOG00000011367 AllianceGenome:RGD:1311866
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including heme binding activity; monooxygenase activity; and protein homodimerization activity. Involved in response to cesium ion and response to ionizing radiation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in artery disease (multiple); brain infarction; obesity; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1B. Orthologous to human CYP2R1 (cytochrome P450 family 2 subfamily R member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 60.0), Liver (RPKM 49.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (178166984..178232191, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (168749302..168798079, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (184060521..184106604, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased expression of cyp2r1 in liver and kidney of rats exposed to 137 cesium suggests a physiological adaptation in response to rise in vitamin D level.
Title: Vitamin D metabolism impairment in the rat's offspring following maternal exposure to 137cesium.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D3 vitamins binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables vitamin D3 25-hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcitriol biosynthetic process from calciol	ISO Inferred from Sequence Orthology more info
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ionizing radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within vitamin D metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: vitamin D 25-hydroxylase

NP_001101969.1

EC 1.14.14.24

NP_001388556.1

EC 1.14.14.24

XP_017444878.2

EC 1.14.14.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.