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    Ckmt1 creatine kinase, mitochondrial 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29593, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ckmt1provided by RGD
    Official Full Name
    creatine kinase, mitochondrial 1provided by RGD
    Primary source
    RGD:61976
    See related
    EnsemblRapid:ENSRNOG00000014573 AllianceGenome:RGD:61976
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ckmt1b
    Summary
    Enables creatine kinase activity and identical protein binding activity. Involved in several processes, including cerebellum development; digestive tract development; and skeletal muscle tissue development. Located in mitochondrial inner-outer membrane contact site and perikaryon. Biomarker of status epilepticus. Orthologous to several human genes including CKMT1B (creatine kinase, mitochondrial 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 720.2), Kidney (RPKM 262.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ckmt1 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128783408..128789485)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108329859..108335760)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113318559..113324459)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene tumor protein p53 binding protein 1 Neighboring gene microtubule-associated protein 1A Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene stereocilin Neighboring gene cation channel, sperm associated 2 Neighboring gene protein disulfide isomerase family A, member 3 Neighboring gene RNA, U105C small nucleolar

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Location and regulation of octameric mitochondrial creatine kinase in the contact sites. Kottke M, et al. Biochim Biophys Acta, 1991 Jan 30. PMID 1998693
    2. Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion in situ, roles of tubulin, and mitochondrial creatine kinase. Monge C, et al. Mol Cell Biochem, 2008 Nov. PMID 18629616
    3. Mitochondrial creatine kinase functional development in post-natal rat skeletal muscle. A combined polarographic/31P NMR study. Kernec F, et al. Mol Cell Biochem, 1999 Apr. PMID 10391136
    4. Compartmentation of multiple forms of creatine kinase in the distal nephron of the rat kidney. Friedman DL, et al. J Biol Chem, 1991 Nov 25. PMID 1939264
    5. Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models. Kim DW, et al. BMC Neurosci, 2010 Oct 28. PMID 20979657, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the beta-alanine administration was able to inhibit the enzyme pyruvate kinase, cytosolic creatine kinase, and adenylate kinase activities in cerebral cortex, and increase in cerebellum.
      Title: Effects of β-alanine administration on selected parameters of oxidative stress and phosphoryltransfer network in cerebral cortex and cerebellum of rats.
    2. The role of ubiquitous mitochondrial creatine kinase (uMtCK) reaction in regulation of mitochondrial respiration was studied in purified preparations of rat brain synaptosomes and mitochondria.
      Title: Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion in situ, roles of tubulin, and mitochondrial creatine kinase.
    3. In chronic epilepsy rats, uMtCK immunoreactivity is markedly reduced in hippocampal CA1-3 pyramidal cells and hilar neurons due to massive neuronal loss.
      Title: Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables creatine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables creatine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables creatine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cerebellum development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in digestive tract development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in kidney development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphocreatine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphocreatine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in skeletal muscle tissue development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner-outer membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    creatine kinase U-type, mitochondrial
    Names
    U-MtCK
    acidic-type mitochondrial creatine kinase
    creatine kinase, mitochondrial 1, ubiquitous
    creatine kinase, mitochondrial 1B
    mia-CK
    ubiquitous mitochondrial creatine kinase
    NP_001012756.1
    XP_006234892.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012738.1 → NP_001012756.1  creatine kinase U-type, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001012756.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091335
      UniProtKB/Swiss-Prot
      P25809
      UniProtKB/TrEMBL
      Q5BJT9
      Related
      ENSRNOP00000044253.3, ENSRNOT00000051354.5
      Conserved Domains (1) summary
      cd00716
      Location:50 → 407
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      128783408..128789485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234830.5 → XP_006234892.1  creatine kinase U-type, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006234892.1

      UniProtKB/Swiss-Prot
      P25809
      UniProtKB/TrEMBL
      Q5BJT9
      Conserved Domains (1) summary
      cd00716
      Location:50 → 407
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25809.1 GenPept UniProtKB/Swiss-Prot:P25809

    Gene LinkOut

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