Spag11a sperm associated antigen 11A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spag11aprovided by RGD
Official Full Name: sperm associated antigen 11Aprovided by RGD
Primary source: RGD:628905
See related: EnsemblRapid:ENSRNOG00000013957 AllianceGenome:RGD:628905
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bin1b; Spag11; Spag11b
Summary: Predicted to be involved in antimicrobial humoral response and negative regulation of interleukin-1 production. Predicted to be located in cell surface and extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 16q12.5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (77384755..77386496, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (70682326..70684067, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (75666439..75668180, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ablation of the sperm-associated antigen 11A (SPAG11A) protein by active immunization promotes epididymal oncogenesis in the rat.
Title: Ablation of the sperm-associated antigen 11A (SPAG11A) protein by active immunization promotes epididymal oncogenesis in the rat.
siRNA-mediated knockdown of sperm-associated antigen 11a (Spag11a) mRNA in epididymal primary epithelial cells affects proliferation: a transcriptome analyses.
Title: siRNA-mediated knockdown of sperm-associated antigen 11a (Spag11a) mRNA in epididymal primary epithelial cells affects proliferation: a transcriptome analyses.
Androgen receptor and NF-kappaB proteins bind to the upstream regulatory sequences of the rat Spag11e gene to regulate expression.
Title: Transcriptional regulation of the rat sperm-associated antigen 11e (Spag 11e) gene during endotoxin challenge.
evidence suggests SPAG11E expression in epididymis has a role in sperm motility: SPAG11E expression is down-regulated in epididymitis (associated with decreased sperm motility); exogenous SPAG11E corrects sperm motility
Title: Lipopolysaccharide-induced epididymitis disrupts epididymal beta-defensin expression and inhibits sperm motility in rats.
Data show that Bin1b can bind to the sperm head in different regions of the epididymis with varied binding patterns, and can induce progressive sperm motility in immotile immature sperm.
Title: An epididymis-specific beta-defensin is important for the initiation of sperm maturation.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IEA Inferred from Electronic Annotation more info
involved_in antifungal humoral response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-1 alpha production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sperm-associated antigen 11A

Names: EP2 protein; anti-microbial-like protein BIN-1B; antimicrobial-like protein Bin-1b; sperm associated antigen 11B; sperm-associated antigen 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.