Cisd1 CDGSH iron sulfur domain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cisd1provided by RGD
Official Full Name: CDGSH iron sulfur domain 1provided by RGD
Primary source: RGD:1309529
See related: AllianceGenome:RGD:1309529
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MitoNEET; RGD1309529
Summary: Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; L-cysteine transaminase activity; and protein homodimerization activity. Predicted to be involved in intracellular iron ion homeostasis and protein maturation by [2Fe-2S] cluster transfer. Predicted to act upstream of or within regulation of cellular respiration. Located in cytoplasmic side of mitochondrial outer membrane. Orthologous to human CISD1 (CDGSH iron sulfur domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 1837.9), Heart (RPKM 1394.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (17254462..17267843)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (17255302..17268688)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (18493538..18506923)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MitoNEET prevents iron overload-induced insulin resistance in H9c2 cells through regulation of mitochondrial iron.
Title: MitoNEET prevents iron overload-induced insulin resistance in H9c2 cells through regulation of mitochondrial iron.
MiR-127-3p targeting CISD1 regulates autophagy in hypoxic-ischemic cortex.
Title: MiR-127-3p targeting CISD1 regulates autophagy in hypoxic-ischemic cortex.
MicroRNA-127 targets mitoNEET, which inhibits neurite outgrowth, induces cell apoptosis and contributes to physiological dysfunction after spinal cord transection
Title: MicroRNA-127 targeting of mitoNEET inhibits neurite outgrowth, induces cell apoptosis and contributes to physiological dysfunction after spinal cord transection.
mito- NEET is an important iron-containing protein involved in the control of maximal mitochondrial respiratory rates [mitoNEET]
Title: MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity.
describes methods for isolating mitochondrial membrane fractions that are enriched in mitoNEET, generating constructs for the expression of recombinant mitoNEET protein and analyzing the 2Fe-2S cluster of mitoNEET in vitro
Title: Chapter 13 Localization and function of the 2Fe-2S outer mitochondrial membrane protein mitoNEET.
mitoNEET is located in mitochondrial fraction of rat brain, liver and skeletal muscle.
Title: Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 2 iron, 2 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables L-cysteine transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-cysteine transaminase activity	ISO Inferred from Sequence Orthology more info
enables L-cysteine transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation by [2Fe-2S] cluster transfer	ISO Inferred from Sequence Orthology more info
involved_in protein maturation by [2Fe-2S] cluster transfer	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cellular respiration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic side of mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CDGSH iron-sulfur domain-containing protein 1

Names: cysteine transaminase CISD1

NP_001099855.1

EC 2.6.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106385.2 → NP_001099855.1 CDGSH iron-sulfur domain-containing protein 1

See identical proteins and their annotated locations for NP_001099855.1

Status: PROVISIONAL

Source sequence(s)

BC159419

UniProtKB/Swiss-Prot

B0K020

UniProtKB/TrEMBL

A0A8I6A430

Conserved Domains (2) summary

smart00704
Location:55 → 93

ZnF_CDGSH; CDGSH-type zinc finger. Function unknown

pfam10660
Location:12 → 41

MitoNEET_N; Iron-containing outer mitochondrial membrane protein N-terminus