Gpr108 G protein-coupled receptor 108 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr108provided by RGD
Official Full Name: G protein-coupled receptor 108provided by RGD
Primary source: RGD:735149
See related: EnsemblRapid:ENSRNOG00000046128 AllianceGenome:RGD:735149
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in negative regulation of toll-like receptor signaling pathway. Predicted to be located in cis-Golgi network membrane and trans-Golgi network. Predicted to be active in Golgi apparatus and membrane. Orthologous to human GPR108 (G protein-coupled receptor 108). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 116.5), Lung (RPKM 107.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (2207716..2218738, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (2120740..2131771, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (9704300..9714767)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_17747-17748:1031760580:1 (e-PCR)
- UniSTS:268393

RH131500 (e-PCR)
- UniSTS:214783

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cis-Golgi network membrane	IEA Inferred from Electronic Annotation more info
located_in cis-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein GPR108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199399.1 → NP_955431.1 protein GPR108 precursor

See identical proteins and their annotated locations for NP_955431.1

Status: PROVISIONAL

Source sequence(s)

BC061996

UniProtKB/Swiss-Prot

M0R518, Q6P6V6

Related

ENSRNOP00000097991.2, ENSRNOT00000111815.2

Conserved Domains (1) summary

pfam06814
Location:248 → 536

Lung_7-TM_R; Lung seven transmembrane receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

2207716..2218738 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244285.5 → XP_006244347.1 protein GPR108 isoform X1

UniProtKB/Swiss-Prot

M0R518, Q6P6V6

Conserved Domains (1) summary

pfam06814
Location:248 → 547

Lung_7-TM_R; Lung seven transmembrane receptor
XM_039083463.2 → XP_038939391.1 protein GPR108 isoform X3

UniProtKB/TrEMBL

A0A8I6AEE0, A0A8L2QWL5

Related

ENSRNOP00000064473.2, ENSRNOT00000075403.3

Conserved Domains (1) summary

pfam06814
Location:230 → 517

Lung_7-TM_R; Lung seven transmembrane receptor
XM_006244286.4 → XP_006244348.1 protein GPR108 isoform X2

UniProtKB/TrEMBL

A0A8I6AEE0

Conserved Domains (1) summary

pfam06814
Location:229 → 528

Lung_7-TM_R; Lung seven transmembrane receptor
XM_063267065.1 → XP_063123135.1 protein GPR108 isoform X5

UniProtKB/TrEMBL

A6KQR1
XM_063267064.1 → XP_063123134.1 protein GPR108 isoform X5

UniProtKB/TrEMBL

A6KQR1
XM_063267063.1 → XP_063123133.1 protein GPR108 isoform X4

UniProtKB/TrEMBL

A6KQR1
XM_063267066.1 → XP_063123136.1 protein GPR108 isoform X6

UniProtKB/TrEMBL

A6KQR1