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    Asb18 ankyrin repeat and SOCS box-containing 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316614, updated on 9-Dec-2024

    Summary

    Official Symbol
    Asb18provided by RGD
    Official Full Name
    ankyrin repeat and SOCS box-containing 18provided by RGD
    Primary source
    RGD:1310850
    See related
    EnsemblRapid:ENSRNOG00000019557 AllianceGenome:RGD:1310850
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB18 (ankyrin repeat and SOCS box containing 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 85.6), Muscle (RPKM 70.9) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Asb18 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (97979018..98043609, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (90531350..90595953, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (97085234..97151832, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 Neighboring gene uncharacterized LOC134480609 Neighboring gene gastrulation brain homeobox 2 Neighboring gene uncharacterized LOC102554789 Neighboring gene IQ motif containing with AAA domain 1 Neighboring gene atypical chemokine receptor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    ankyrin repeat and SOCS box protein 18

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108231.1NP_001101701.1  ankyrin repeat and SOCS box protein 18

      See identical proteins and their annotated locations for NP_001101701.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473997
      UniProtKB/TrEMBL
      A0A8I6A7E9, A6JQK8, D3ZU92
      Related
      ENSRNOP00000044574.5, ENSRNOT00000040169.6
      Conserved Domains (5) summary
      cd00204
      Location:122237
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03723
      Location:420467
      SOCS_ASB4_ASB18; SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the ...
      pfam12796
      Location:124214
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:283334
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:122149
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      97979018..98043609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083755.2XP_038939683.1  ankyrin repeat and SOCS box protein 18 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7E9
      Related
      ENSRNOP00000104186.1, ENSRNOT00000131821.1
      Conserved Domains (4) summary
      PTZ00322
      Location:242325
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd03723
      Location:379426
      SOCS_ASB4_ASB18; SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the ...
      sd00045
      Location:81108
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:115208
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_039083757.2XP_038939685.1  ankyrin repeat and SOCS box protein 18 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A7E9
      Conserved Domains (4) summary
      PTZ00322
      Location:196279
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd03723
      Location:333380
      SOCS_ASB4_ASB18; SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the ...
      sd00045
      Location:3562
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:69162
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_063267314.1XP_063123384.1  ankyrin repeat and SOCS box protein 18 isoform X4

    4. XM_039083756.2XP_038939684.1  ankyrin repeat and SOCS box protein 18 isoform X2

      Conserved Domains (3) summary
      PTZ00322
      Location:254362
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:93120
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:127220
      Ank_2; Ankyrin repeats (3 copies)