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    Antkmt adenine nucleotide translocase lysine methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287150, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Antkmtprovided by RGD
    Official Full Name
    adenine nucleotide translocase lysine methyltransferaseprovided by RGD
    Primary source
    RGD:1306126
    See related
    EnsemblRapid:ENSRNOG00000019684 AllianceGenome:RGD:1306126
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam173a; RGD1306126
    Summary
    Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine trimethylation and regulation of mitochondrial ATP synthesis coupled proton transport. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrion. Orthologous to human ANTKMT (adenine nucleotide translocase lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 97.5), Kidney (RPKM 86.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Antkmt in Genome Data Viewer
    Location:
    10q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15316797..15320950, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14812274..14814798, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15160037..15161895, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene hydroxyacylglutathione hydrolase-like Neighboring gene coiled-coil domain containing 78 Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene F-box and leucine-rich repeat protein 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration. Małecki JM, et al. J Biol Chem, 2019 Aug 2. PMID 31213526, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125270

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-lysine trimethylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial ATP synthesis coupled proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenine nucleotide translocase lysine N-methyltransferase
    Names
    family with sequence similarity 173, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127447.1 → NP_001120919.1  adenine nucleotide translocase lysine N-methyltransferase

      See identical proteins and their annotated locations for NP_001120919.1

      Status: VALIDATED

      Source sequence(s)
      AW918226, BF284299
      UniProtKB/TrEMBL
      A6HD51, A6HD52, D4A1T7
      Related
      ENSRNOP00000026641.3, ENSRNOT00000026641.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15316797..15320950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085365.2 → XP_038941293.1  adenine nucleotide translocase lysine N-methyltransferase isoform X2

    2. XM_039085364.2 → XP_038941292.1  adenine nucleotide translocase lysine N-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4W6, A6HD52
      Related
      ENSRNOP00000085813.1, ENSRNOT00000115955.2
    Nucleotide Protein Strain
    Heading Accession and Version

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