U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Saraf store-operated calcium entry-associated regulatory factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290796, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sarafprovided by RGD
    Official Full Name
    store-operated calcium entry-associated regulatory factorprovided by RGD
    Primary source
    RGD:1303011
    See related
    EnsemblRapid:ENSRNOG00000012329 AllianceGenome:RGD:1303011
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem66
    Summary
    Predicted to be involved in regulation of store-operated calcium entry. Predicted to be located in endoplasmic reticulum and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SARAF (store-operated calcium entry associated regulatory factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 569.2), Lung (RPKM 415.0) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Saraf in Genome Data Viewer
    Location:
    16q12.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (64720404..64738653, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (58017231..58035481, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (61735189..61753438, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene RAB interacting factor, pseudogene 1 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene uncharacterized LOC134482511 Neighboring gene uncharacterized LOC134482512 Neighboring gene leptin receptor overlapping transcript-like 1 Neighboring gene membrane bound O-acyltransferase domain containing 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transmembrane protein 66 attenuates neointimal hyperplasia after carotid artery injury by SOCE inactivation. Yang J, et al. Mol Med Rep, 2019 Aug. PMID 31173198
    2. SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling. Palty R, et al. Cell, 2012 Apr 13. PMID 22464749
    3. Cone arrestin identified by targeting expression of a functional family. Craft CM, et al. J Biol Chem, 1994 Feb 11. PMID 8308033
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM66 attenuates neointimal hyperplasia after carotid artery injury by SOCE inactivation.
      Title: Transmembrane protein 66 attenuates neointimal hyperplasia after carotid artery injury by SOCE inactivation.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC93866

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of store-operated calcium entry IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of store-operated calcium entry ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of store-operated calcium entry ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    store-operated calcium entry-associated regulatory factor
    Names
    SOCE-associated regulatory factor
    arrestin-E
    transmembrane protein 66

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004213.1 → NP_001004213.1  store-operated calcium entry-associated regulatory factor precursor

      See identical proteins and their annotated locations for NP_001004213.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078979
      UniProtKB/Swiss-Prot
      Q6AYN2
      UniProtKB/TrEMBL
      A0A8L2Q907, A6IVP3
      Related
      ENSRNOP00000016792.7, ENSRNOT00000016792.8
      Conserved Domains (1) summary
      pfam06682
      Location:25 → 334
      SARAF; SOCE-associated regulatory factor of calcium homoeostasis

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      64720404..64738653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYN2.1 GenPept UniProtKB/Swiss-Prot:Q6AYN2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools