U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dpep3 dipeptidase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364994, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dpep3provided by RGD
    Official Full Name
    dipeptidase 3provided by RGD
    Primary source
    RGD:1305484
    See related
    EnsemblRapid:ENSRNOG00000019757 AllianceGenome:RGD:1305484
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dipeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in acrosomal vesicle and plasma membrane. Orthologous to human DPEP3 (dipeptidase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 90.9), Lung (RPKM 17.1) and 2 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dpep3 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50778079..50786451, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33868229..33876609, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37946516..37955199, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098640 Neighboring gene solute carrier family 12 member 4 Neighboring gene lecithin cholesterol acyltransferase Neighboring gene dipeptidase 2 Neighboring gene dihydrouridine synthase 2 Neighboring gene DEAD-box helicase 28

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular characterization and expression of dipeptidase 3, a testis-specific membrane-bound dipeptidase: complex formation with TEX101, a germ-cell-specific antigen in the mouse testis. Yoshitake H, et al. J Reprod Immunol, 2011 Aug. PMID 21724266
    2. Identification of two additional members of the membrane-bound dipeptidase family. Habib GM, et al. FASEB J, 2003 Jul. PMID 12738806
    3. Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans. Kogo H, et al. J Hum Genet, 2010 May. PMID 20339383
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC94276

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dipeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    dipeptidase 3
    Names
    putative membrane-bound dipeptidase 3
    NP_001008384.1
    XP_006255579.1
    XP_038953841.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008383.1 → NP_001008384.1  dipeptidase 3 precursor

      See identical proteins and their annotated locations for NP_001008384.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085826
      UniProtKB/Swiss-Prot
      Q5U2X4
      UniProtKB/TrEMBL
      A6IYV1
      Related
      ENSRNOP00000026809.4, ENSRNOT00000026809.7
      Conserved Domains (1) summary
      pfam01244
      Location:84 → 404
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50778079..50786451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255517.5 → XP_006255579.1  dipeptidase 3 isoform X1

      See identical proteins and their annotated locations for XP_006255579.1

      UniProtKB/Swiss-Prot
      Q5U2X4
      UniProtKB/TrEMBL
      A6IYV1
      Conserved Domains (1) summary
      pfam01244
      Location:84 → 404
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    2. XM_039097913.2 → XP_038953841.1  dipeptidase 3 isoform X2

      Related
      ENSRNOP00000104061.1, ENSRNOT00000149904.1
      Conserved Domains (1) summary
      pfam01244
      Location:84 → 361
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2X4.1 GenPept UniProtKB/Swiss-Prot:Q5U2X4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools