Kctd8 potassium channel tetramerization domain containing 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kctd8provided by RGD
Official Full Name: potassium channel tetramerization domain containing 8provided by RGD
Primary source: RGD:1312020
See related: EnsemblRapid:ENSRNOG00000063710 AllianceGenome:RGD:1312020
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential. Predicted to be involved in protein homooligomerization and regulation of presynaptic membrane potential. Predicted to act upstream of or within regulation of G protein-coupled receptor signaling pathway. Predicted to be part of receptor complex. Predicted to be active in postsynapse and presynaptic active zone membrane. Orthologous to human KCTD8 (potassium channel tetramerization domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 53.9), Kidney (RPKM 9.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (39127210..39372118)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (38773274..39018182)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (61912193..62158730, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D14Got54 (e-PCR)
- UniSTS:113554

D14Got56 (e-PCR)
- UniSTS:113101

RH138038 (e-PCR)
- UniSTS:220125

D14Got57 (e-PCR)
- UniSTS:115171

RH138830 (e-PCR)
- UniSTS:220917

AU046510 (e-PCR)
- UniSTS:115960

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BTB/POZ domain-containing protein KCTD8

Names: potassium channel tetramerisation domain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.