Rpusd4 RNA pseudouridine synthase D4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rpusd4provided by RGD
Official Full Name: RNA pseudouridine synthase D4provided by RGD
Primary source: RGD:1311268
See related: EnsemblRapid:ENSRNOG00000011567 AllianceGenome:RGD:1311268
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311268
Summary: Predicted to enable mitochondrial ribosomal large subunit rRNA binding activity; pseudouridine synthase activity; and tRNA binding activity. Predicted to be involved in positive regulation of mitochondrial translation and pseudouridine synthesis. Predicted to be located in mitochondrial matrix; nucleoplasm; and ribonucleoprotein granule. Orthologous to human RPUSD4 (RNA pseudouridine synthase D4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 68.9), Heart (RPKM 67.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (41875217..41884702)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (33617384..33626873)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (36467706..36477190)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131616 (e-PCR)
- UniSTS:214899

RH125999 (e-PCR)
- UniSTS:162711

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mitochondrial ribosomal large subunit rRNA binding	ISO Inferred from Sequence Orthology more info
enables pseudouridine synthase activity	IEA Inferred from Electronic Annotation more info
enables pseudouridine synthase activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables tRNA pseudouridine synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA pseudouridine synthesis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA pseudouridine synthesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in pseudouridine synthesis	IEA Inferred from Electronic Annotation more info
involved_in rRNA pseudouridine synthesis	IEA Inferred from Electronic Annotation more info
involved_in rRNA pseudouridine synthesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pseudouridylate synthase RPUSD4, mitochondrial

Names: RNA pseudouridylate synthase domain containing 4; RNA pseudouridylate synthase domain-containing protein 4; mitochondrial RNA pseudouridine synthase Rpusd4

NP_001020455.1

EC 5.4.99.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025284.1 → NP_001020455.1 pseudouridylate synthase RPUSD4, mitochondrial

See identical proteins and their annotated locations for NP_001020455.1

Status: PROVISIONAL

Source sequence(s)

BC098023

UniProtKB/Swiss-Prot

Q4QQT0

UniProtKB/TrEMBL

A6JYK3

Related

ENSRNOP00000015670.5, ENSRNOT00000015670.8

Conserved Domains (1) summary

cd02869
Location:106 → 329

PseudoU_synth_RluA_like; Pseudouridine synthase, RluA family