Zdhhc1 zinc finger, DHHC domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zdhhc1provided by MGI
Official Full Name: zinc finger, DHHC domain containing 1provided by MGI
Primary source: MGI:MGI:1918046
See related: Ensembl:ENSMUSG00000039199 AllianceGenome:MGI:1918046
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DHHC-1; 4432412D04Rik
Summary: Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of protein-containing complex assembly. Acts upstream of or within protein palmitoylation. Located in endosome membrane. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; heart; and lung. Orthologous to human ZDHHC1 (zinc finger DHHC-type containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lung adult (RPKM 28.6), ovary adult (RPKM 27.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.04 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106199055..106223694, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (105472419..105497062, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antiviral innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-L-cysteine S-palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to endosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein oligomerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: palmitoyltransferase ZDHHC1

Names: probable palmitoyltransferase ZDHHC1; zinc finger DHHC domain-containing protein 1

NP_001344181.1

EC 2.3.1.225

NP_001365935.1

EC 2.3.1.225

NP_001365936.1

EC 2.3.1.225

NP_001365937.1

EC 2.3.1.225

NP_001365938.1

EC 2.3.1.225

NP_001365939.1

EC 2.3.1.225

NP_001365940.1

EC 2.3.1.225

NP_780369.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357252.2 → NP_001344181.1 palmitoyltransferase ZDHHC1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2), as well as variant 5, encodes isoform 2.

Source sequence(s)

AC090480, AC151573

UniProtKB/TrEMBL

B7ZMY5

Conserved Domains (1) summary

pfam01529
Location:126 → 281

DHHC; DHHC palmitoyltransferase
NM_001379006.1 → NP_001365935.1 palmitoyltransferase ZDHHC1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3), as well as variants 1 and 4, encodes isoform 1.

Source sequence(s)

AC090480, AC151573

UniProtKB/Swiss-Prot

Q0VE36, Q8BJ24, Q8R0N9

Conserved Domains (1) summary

pfam01529
Location:126 → 281

DHHC; DHHC palmitoyltransferase
NM_001379007.1 → NP_001365936.1 palmitoyltransferase ZDHHC1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (4), as well as variants 1 and 3, encodes isoform 1.

Source sequence(s)

AC090480, AC151573

UniProtKB/Swiss-Prot

Q0VE36, Q8BJ24, Q8R0N9

Conserved Domains (1) summary

pfam01529
Location:126 → 281

DHHC; DHHC palmitoyltransferase
NM_001379008.1 → NP_001365937.1 palmitoyltransferase ZDHHC1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (5), as well as variant 2, encodes isoform 2.

Source sequence(s)

AC090480, AC151573

UniProtKB/TrEMBL

B7ZMY5

Conserved Domains (1) summary

pfam01529
Location:126 → 281

DHHC; DHHC palmitoyltransferase
NM_001379009.1 → NP_001365938.1 palmitoyltransferase ZDHHC1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (6), as well as variants 7 and 8, encodes isoform 3.

Source sequence(s)

AC090480, AC151573

Conserved Domains (1) summary

pfam01529
Location:126 → 281

DHHC; DHHC palmitoyltransferase
NM_001379010.1 → NP_001365939.1 palmitoyltransferase ZDHHC1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (7), as well as variants 6 and 8, encodes isoform 3.

Source sequence(s)

AC090480, AC151573

Conserved Domains (1) summary

pfam01529
Location:126 → 281

DHHC; DHHC palmitoyltransferase
NM_001379011.1 → NP_001365940.1 palmitoyltransferase ZDHHC1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (8), as well as variants 6 and 7, encodes isoform 3.

Source sequence(s)

AC090480, AC151573

Conserved Domains (1) summary

pfam01529
Location:126 → 281

DHHC; DHHC palmitoyltransferase
NM_175160.5 → NP_780369.1 palmitoyltransferase ZDHHC1 isoform 1

See identical proteins and their annotated locations for NP_780369.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).

Source sequence(s)

AC090480, AC151573

Consensus CDS

CCDS22603.1

UniProtKB/Swiss-Prot

Q0VE36, Q8BJ24, Q8R0N9

Related

ENSMUSP00000148381.2, ENSMUST00000212303.2

Conserved Domains (1) summary

pfam01529
Location:126 → 281

DHHC; DHHC palmitoyltransferase

RNA

NR_166407.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC090480, AC151573
NR_166408.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC090480, AC151573
NR_166409.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC090480, AC151573