Daglb diacylglycerol lipase, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Daglbprovided by MGI
Official Full Name: diacylglycerol lipase, betaprovided by MGI
Primary source: MGI:MGI:2442032
See related: Ensembl:ENSMUSG00000039206 AllianceGenome:MGI:2442032
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E330036I19Rik
Summary: Enables monoacylglycerol lipase activity and triacylglycerol lipase activity. Involved in positive regulation of triglyceride catabolic process; regulation of inflammatory response; and unsaturated fatty acid metabolic process. Acts upstream of or within cannabinoid biosynthetic process; monoacylglycerol biosynthetic process; and neuroblast proliferation. Predicted to be located in nucleoplasm. Predicted to be active in plasma membrane. Is expressed in brain; liver; and spinal cord. Orthologous to human DAGLB (diacylglycerol lipase beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 20.1), mammary gland adult (RPKM 16.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 82.19 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (143450239..143490197)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (143464484..143504442)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction.
Title: Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction.
DAGL-Beta Functions as a PUFA-Specific Triacylglycerol Lipase in Macrophages.
Title: DAGL-Beta Functions as a PUFA-Specific Triacylglycerol Lipase in Macrophages.
Authors identify DAGLbeta pathways as a means for attenuating DC inflammatory signaling while sparing critical adaptive immune functions and further expand the utility of targeting lipid pathways for immunomodulation.
Title: Diacylglycerol Lipase-β Is Required for TNF-α Response but Not CD8(+) T Cell Priming Capacity of Dendritic Cells.
The control of adult neurogenesis in the hippocampus and subventricular zone is compromised in the DAGLalpha(-/-) and/or DAGLbeta(-/-) mice.
Title: Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Ertd559e (e-PCR), detects polymorphism
- UniSTS:167446

UniSTS:498230 (e-PCR)
- UniSTS:498230

Daglb (e-PCR), detects polymorphism
- UniSTS:498230

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables lipase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoacylglycerol lipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables triacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of arachidonate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cannabinoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diacylglycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in icosanoid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoacylglycerol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of triglyceride catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: diacylglycerol lipase-beta

Names: DAGL-beta; DAGLbeta; DGL-beta; PUFA-specific triacylglycerol lipase; sn1-specific diacylglycerol lipase beta

NP_659164.2

EC 3.1.1.116

EC 3.1.1.3

XP_006504761.1

EC 3.1.1.116

EC 3.1.1.3

XP_006504763.1

EC 3.1.1.116

EC 3.1.1.3

XP_030110321.1

EC 3.1.1.116

EC 3.1.1.3

XP_036020998.1

EC 3.1.1.116

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144915.3 → NP_659164.2 diacylglycerol lipase-beta

See identical proteins and their annotated locations for NP_659164.2

Status: VALIDATED

Source sequence(s)

AK136372, BE992098, BY314231, CO043884

Consensus CDS

CCDS39370.1

UniProtKB/Swiss-Prot

Q8BU39, Q8BU97, Q8BV05, Q91WC9

Related

ENSMUSP00000043088.9, ENSMUST00000045593.12

Conserved Domains (1) summary

cd00519
Location:274 → 507

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

143450239..143490197

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254461.2 → XP_030110321.1 diacylglycerol lipase-beta isoform X3

Conserved Domains (1) summary

cd00519
Location:127 → 360

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
XM_006504698.4 → XP_006504761.1 diacylglycerol lipase-beta isoform X2

Conserved Domains (1) summary

cd00519
Location:147 → 380

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
XM_006504700.3 → XP_006504763.1 diacylglycerol lipase-beta isoform X4

Conserved Domains (1) summary

cd00519
Location:1 → 226

Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...
XM_036165105.1 → XP_036020998.1 diacylglycerol lipase-beta isoform X1

Conserved Domains (1) summary

cl21494
Location:274 → 479

Abhydrolase; alpha/beta hydrolases