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    Spry4 sprouty RTK signaling antagonist 4 [ Mus musculus (house mouse) ]

    Gene ID: 24066, updated on 9-Dec-2024

    Summary

    Official Symbol
    Spry4provided by MGI
    Official Full Name
    sprouty RTK signaling antagonist 4provided by MGI
    Primary source
    MGI:MGI:1345144
    See related
    Ensembl:ENSMUSG00000024427 AllianceGenome:MGI:1345144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sprouty4; A030006O18Rik
    Summary
    Predicted to enable protein kinase inhibitor activity. Acts upstream of or within cellular response to leukemia inhibitory factor and negative regulation of MAP kinase activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; germ layer; and nervous system. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 10.0), limb E14.5 (RPKM 8.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Spry4 in Genome Data Viewer
    Location:
    18 B3; 18 20.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (38719300..38734400, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (38586247..38601347, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41704 Neighboring gene STARR-seq mESC enhancer starr_44367 Neighboring gene STARR-seq mESC enhancer starr_44374 Neighboring gene STARR-seq mESC enhancer starr_44375 Neighboring gene STARR-seq mESC enhancer starr_44376 Neighboring gene STARR-seq mESC enhancer starr_44377 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene Neighboring gene Rho GTPase activating protein 26 Neighboring gene predicted gene, 19774 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011898.3NP_036028.2  protein sprouty homolog 4

      See identical proteins and their annotated locations for NP_036028.2

      Status: VALIDATED

      Source sequence(s)
      AC151580, AK034201, AK048122, BC050944
      Consensus CDS
      CCDS29202.1
      UniProtKB/Swiss-Prot
      Q543R1, Q9QXV7, Q9WTP2
      Related
      ENSMUSP00000025295.7, ENSMUST00000025295.8
      Conserved Domains (1) summary
      pfam05210
      Location:165267
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      38719300..38734400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161148.1XP_036017041.1  protein sprouty homolog 4 isoform X1

      UniProtKB/Swiss-Prot
      Q543R1, Q9QXV7, Q9WTP2
      Conserved Domains (1) summary
      pfam05210
      Location:165267
      Sprouty; Sprouty protein (Spry)