Cylc1 cylicin, basic protein of sperm head cytoskeleton 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cylc1provided by MGI
Official Full Name: cylicin, basic protein of sperm head cytoskeleton 1provided by MGI
Primary source: MGI:MGI:1914657
See related: Ensembl:ENSMUSG00000073001 AllianceGenome:MGI:1914657
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930401M13Rik
Summary: Acts upstream of or within maintenance of cell number; single fertilization; and spermatogenesis. Predicted to be active in acrosomal matrix. Used to study male infertility. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 8. Orthologous to human CYLC1 (cylicin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 1.2) See more
Orthologs: human all
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Genomic context

Location:: X E1; X 48.2 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (110154024..110169624)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (111110418..111125854)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice.
Title: Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within acrosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within acrosome assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular component organization or biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of cell number	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in acrosomal matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in acrosomal matrix	ISO Inferred from Sequence Orthology more info
is_active_in acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in perinuclear theca	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cylicin-1

Names: cylicin I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026134.3 → NP_080410.3 cylicin-1

Status: VALIDATED

Source sequence(s)

LO016976

Consensus CDS

CCDS41103.2

UniProtKB/Swiss-Prot

A0A1B0GR13

Related

ENSMUSP00000147334.2, ENSMUST00000210720.3

Conserved Domains (1) summary

pfam15241
Location:26 → 131

Cylicin_N; Cylicin N-terminus