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    bet-2 Bromo domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181257, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bet-2
    Official Full Name
    Bromo domain-containing protein
    Primary source
    WormBase:WBGene00010199
    Locus tag
    CELE_F57C7.1
    See related
    AllianceGenome:WB:WBGene00010199
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lysine-acetylated histone binding activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in azoospermia; oligospermia; and spermatogenic failure 21. Orthologous to human BRDT (bromodomain testis associated). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bet-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (10569273..10575725)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DM13 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sodium/hydrogen exchanger Neighboring gene PKD/REJ-like domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans. Chamberlin HM, et al. Development, 2000 Feb. PMID 10648230
    2. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
    3. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Bromo domain-containing protein
    NP_001300352.1
    • Confirmed by transcript evidence
    NP_001300353.1
    • Confirmed by transcript evidence
    NP_001366763.1
    • Confirmed by transcript evidence
    NP_509770.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10569273..10575725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381085.1 → NP_001366763.1  Bromo domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20948
      Conserved Domains (5) summary
      cd05498
      Location:556 → 657
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      COG5076
      Location:429 → 661
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam15301
      Location:969 → 1049
      SLAIN; SLAIN motif-containing family
      pfam17035
      Location:860 → 929
      BET; Bromodomain extra-terminal - transcription regulation
      cl02556
      Location:282 → 388
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    2. NM_077369.7 → NP_509770.2  Bromo domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509770.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20947
      Conserved Domains (3) summary
      cd05497
      Location:282 → 388
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:556 → 657
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      COG5076
      Location:429 → 661
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

    3. NM_001313424.6 → NP_001300353.1  Bromo domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWB8
      Conserved Domains (3) summary
      cd05498
      Location:556 → 657
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      COG5076
      Location:429 → 661
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      cl02556
      Location:282 → 388
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    4. NM_001313423.6 → NP_001300352.1  Bromo domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASR2
      Conserved Domains (3) summary
      cd05497
      Location:282 → 388
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:556 → 657
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      COG5076
      Location:429 → 661
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    Nucleotide Protein
    Heading Accession and Version

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