hsd-1 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: hsd-1
Official Full Name: 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1
Primary source: WormBase:WBGene00012394
Locus tag: CELE_Y6B3B.11
See related: AllianceGenome:WB:WBGene00012394
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity. Involved in nematode larval development and sterol biosynthetic process. Predicted to be located in membrane. Is expressed in XXXL and XXXR. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Orthologous to several human genes including SDR42E1 (short chain dehydrogenase/reductase family 42E, member 1). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

HSD-1-mediated signal activates insulin/IGF-I signaling in a cell non-autonomous fashion
Title: Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cholesterol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables steroid delta-isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

Preferred Names: 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1

NP_493402.1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain