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    hsd-1 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1 [ Caenorhabditis elegans ]

    Gene ID: 189371, updated on 9-Dec-2024

    Summary

    Official Symbol
    hsd-1
    Official Full Name
    3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1
    Primary source
    WormBase:WBGene00012394
    Locus tag
    CELE_Y6B3B.11
    See related
    AllianceGenome:WB:WBGene00012394
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity. Involved in nematode larval development and sterol biosynthetic process. Predicted to be located in membrane. Is expressed in XXXL and XXXR. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Orthologous to several human genes including SDR42E1 (short chain dehydrogenase/reductase family 42E, member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See hsd-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (13720125..13724453, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene putative ceramide synthase lagr-1 Neighboring gene ncRNA Neighboring gene ncRNA

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1
    NP_493402.1
    • Predicted

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13720125..13724453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061001.1NP_493402.1  3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493402.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XWF0
      Conserved Domains (1) summary
      cl21454
      Location:47407
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins