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    nhr-45 Nuclear Hormone Receptor family [ Caenorhabditis elegans ]

    Gene ID: 180738, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-45
    Official Full Name
    Nuclear Hormone Receptor family
    Primary source
    WormBase:WBGene00003635
    Locus tag
    CELE_F16H11.5
    See related
    AllianceGenome:WB:WBGene00003635
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-45 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (4656433..4660318, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Homeobox protein ceh-1 Neighboring gene Major facilitator superfamily domain-containing protein 12 Neighboring gene Transmembrane protein 135 homolog Neighboring gene SPLDEEDFAPESPLQ-amide

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear hormone receptors promote gut and glia detoxifying enzyme induction and protect C. elegans from the mold P. brevicompactum. Wallace SW, et al. Cell Rep, 2021 Dec 28. PMID 34965433, Free PMC Article
    2. Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes. Mao K, et al. Cell Metab, 2019 May 7. PMID 30799287, Free PMC Article
    3. Global analysis of dauer gene expression in Caenorhabditis elegans. Wang J, et al. Development, 2003 Apr. PMID 12620986
    4. Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Arda HE, et al. Mol Syst Biol, 2010 May 11. PMID 20461074, Free PMC Article
    5. The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Mao K, et al. Proc Natl Acad Sci U S A, 2022 Dec 6. PMID 36445965, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear Hormone Receptor family
    NP_508797.3
    • Product from WormBase gene class nhr;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4656433..4660318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076396.8 → NP_508797.3  Nuclear Hormone Receptor family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508797.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19496
      Conserved Domains (2) summary
      cd06157
      Location:305 → 494
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
      smart00399
      Location:3 → 71
      ZnF_C4; c4 zinc finger in nuclear hormone receptors
    Nucleotide Protein
    Heading Accession and Version

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