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    nhr-14 Nuclear hormone receptor family member nhr-14 [ Caenorhabditis elegans ]

    Gene ID: 181102, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-14
    Official Full Name
    Nuclear hormone receptor family member nhr-14
    Primary source
    WormBase:WBGene00003613
    Locus tag
    CELE_T01B10.4
    See related
    AllianceGenome:WB:WBGene00003613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables steroid hormone binding activity. Involved in defense response to Gram-negative bacterium; negative regulation of protein localization to nucleus; and regulation of innate immune response. Located in nucleus. Is expressed in head and intestinal cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-14 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (8473722..8476178, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Degenerin mec-10 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In Silico Molecular Docking and In Vivo Validation with Caenorhabditis elegans to Discover Molecular Initiating Events in Adverse Outcome Pathway Framework: Case Study on Endocrine-Disrupting Chemicals with Estrogen and Androgen Receptors. Jeong J, et al. Int J Mol Sci, 2019 Mar 10. PMID 30857347, Free PMC Article
    2. Phytoestrogens genistein and daidzein affect immunity in the nematode Caenorhabditis elegans via alterations of vitellogenin expression. Fischer M, et al. Mol Nutr Food Res, 2012 Jun. PMID 22707270
    3. Caenorhabditis elegans NHR-14/HNF4α regulates DNA damage-induced apoptosis through cooperating with cep-1/p53. Sang L, et al. Cell Commun Signal, 2022 Sep 1. PMID 36050770, Free PMC Article
    4. NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling. Rajan M, et al. Elife, 2019 Sep 18. PMID 31532389, Free PMC Article
    5. Identification of an estrogenic hormone receptor in Caenorhabditis elegans. Mimoto A, et al. Biochem Biophys Res Commun, 2007 Dec 28. PMID 17963693

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steroid hormone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-14
    NP_741860.2
    • Confirmed by transcript evidence
    NP_741861.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8473722..8476178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171743.6 → NP_741861.2  Nuclear hormone receptor family member nhr-14 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741861.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02151
      Conserved Domains (2) summary
      cd06960
      Location:20 → 95
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:176 → 322
      HOLI; Ligand binding domain of hormone receptors

    2. NM_171742.6 → NP_741860.2  Nuclear hormone receptor family member nhr-14 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741860.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02151, Q8MPT6, Q9UAN4
      Conserved Domains (2) summary
      cd06960
      Location:20 → 95
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:176 → 322
      HOLI; Ligand binding domain of hormone receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02151.3

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