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    pde-5 putative 3',5'-cyclic phosphodiesterase pde-5 [ Caenorhabditis elegans ]

    Gene ID: 183125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pde-5
    Official Full Name
    putative 3',5'-cyclic phosphodiesterase pde-5
    Primary source
    WormBase:WBGene00016328
    Locus tag
    CELE_C32E12.2
    See related
    AllianceGenome:WB:WBGene00016328
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; 3',5'-cyclic-AMP phosphodiesterase activity; and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including determination of adult lifespan; negative regulation of cGMP-mediated signaling; and response to hydrogen peroxide. Is expressed in AFDL and AFDR. Orthologous to human PDE10A (phosphodiesterase 10A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pde-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (5196073..5200263)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Core-binding factor subunit beta homolog bro-1 Neighboring gene FANCM (Fanconi anemia complex component M) homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TPR_REGION domain-containing protein Neighboring gene Transcription factor sem-2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cGMP dynamics that underlies thermosensation in temperature-sensing neuron regulates thermotaxis behavior in C. elegans. Aoki I, et al. PLoS One, 2022. PMID 36472979, Free PMC Article
    2. GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis. Wang D, et al. J Gen Physiol, 2013 Oct. PMID 24081984, Free PMC Article
    3. The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected]. Beckert U, et al. PLoS One, 2013. PMID 24015261, Free PMC Article
    4. Changes in cGMP levels affect the localization of EGL-4 in AWC in Caenorhabditis elegans. O'Halloran DM, et al. PLoS One, 2012. PMID 22319638, Free PMC Article
    5. The Dunce cAMP phosphodiesterase PDE-4 negatively regulates G alpha(s)-dependent and G alpha(s)-independent cAMP pools in the Caenorhabditis elegans synaptic signaling network. Charlie NK, et al. Genetics, 2006 May. PMID 16624912, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microvillus organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cGMP-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phototransduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to alkaline pH IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to hydrogen peroxide IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative 3',5'-cyclic phosphodiesterase pde-5
    NP_491544.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5196073..5200263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059143.4 → NP_491544.3  putative 3',5'-cyclic phosphodiesterase pde-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491544.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91119
      Conserved Domains (2) summary
      smart00065
      Location:221 → 371
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:464 → 696
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91119.3

    Gene LinkOut

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