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    inx-10 Innexin;Innexin-10 [ Caenorhabditis elegans ]

    Gene ID: 188580, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inx-10
    Official Full Name
    Innexin;Innexin-10
    Primary source
    WormBase:WBGene00002132
    Locus tag
    CELE_T18H9.5
    See related
    AllianceGenome:WB:WBGene00002132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable gap junction hemi-channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Located in gap junction. Is expressed in several structures, including hermaphrodite gonad; neurons; pharynx; rectal epithelium; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See inx-10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (9204661..9207477, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Seven TM Receptor Neighboring gene pseudo Neighboring gene Peptidase A1 domain-containing protein Neighboring gene MeDiaTor Neighboring gene Phosphofurin acidic cluster sorting protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Six innexins contribute to electrical coupling of C. elegans body-wall muscle. Liu P, et al. PLoS One, 2013. PMID 24130800, Free PMC Article
    2. High-Throughput All-Optical Analysis of Synaptic Transmission and Synaptic Vesicle Recycling in Caenorhabditis elegans. Wabnig S, et al. PLoS One, 2015. PMID 26312752, Free PMC Article
    3. ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Guan L, et al. Traffic, 2022 Mar. PMID 34994051
    4. Presynaptic coupling by electrical synapses coordinates a rhythmic behavior by synchronizing the activities of a neuron pair. Choi U, et al. Proc Natl Acad Sci U S A, 2021 May 18. PMID 33972428, Free PMC Article
    5. The Caenorhabditis elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells. Barnes TM, et al. J Neurochem, 1997 Dec. PMID 9375655

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables gap junction hemi-channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in gap junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Innexin;Innexin-10
    NP_001024139.1
    • Confirmed by transcript evidence
    NP_001024140.1
    • Partially confirmed by transcript evidence
    NP_001360570.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9204661..9207477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373070.2 → NP_001360570.1  Innexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WYM8, T2DJN8
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 379
      Innexin

    2. NM_001028969.6 → NP_001024140.1  Innexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024140.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AHN7, T2DJN8
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 380
      Innexin; Innexin

    3. NM_001028968.4 → NP_001024139.1  Innexin-10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024139.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22549
      UniProtKB/TrEMBL
      T2DJN8
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 380
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22549.1

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