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    ubc-24 UBC core domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186057, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ubc-24
    Official Full Name
    UBC core domain-containing protein
    Primary source
    WormBase:WBGene00006719
    Locus tag
    CELE_F49E12.4
    See related
    AllianceGenome:WB:WBGene00006719
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable NEDD8 transferase activity. Predicted to be involved in protein neddylation. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ubc-24 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (8405603..8406927)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Downstream Of DAF-16 (regulated by DAF-16) Neighboring gene Peroxidase skpo-1 Neighboring gene Serpentine receptor class alpha-13 Neighboring gene Transcription factor efl-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. Howard RA, et al. BMC Cell Biol, 2007 Jul 30. PMID 17663792, Free PMC Article
    2. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article
    3. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article
    4. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein modification by small protein conjugation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UBC core domain-containing protein
    NP_495769.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8405603..8406927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063368.5 → NP_495769.2  UBC core domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495769.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20617
      Conserved Domains (1) summary
      smart00212
      Location:17 → 160
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    Nucleotide Protein
    Heading Accession and Version

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