F43C9.2 Calmodulin;EF-hand domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F43C9.2
Official Full Name: Calmodulin;EF-hand domain-containing protein
Primary source: WormBase:WBGene00018376
Locus tag: CELE_F43C9.2
See related: AllianceGenome:WB:WBGene00018376
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity and enzyme regulator activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in congenital myopathy 15. Orthologous to human TNNC2 (troponin C2, fast skeletal type). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F43C9.2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 5

Sequence:: Chromosome: X; NC_003284.9 (4783613..4790327)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F43C9.2 (e-PCR)
- UniSTS:319344

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Calmodulin;EF-hand domain-containing protein

NP_001348806.1

Confirmed by transcript evidence

NP_001348807.2

Confirmed by transcript evidence

NP_508818.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4783613..4790327

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001361802.4 → NP_001348806.1 EF-hand domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2K5AU04

Conserved Domains (1) summary

COG5126
Location:2 → 142

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001361801.1 → NP_001348807.2 Calmodulin [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2K5AU12
NM_076417.7 → NP_508818.1 EF-hand domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508818.1

Status: REVIEWED

UniProtKB/TrEMBL

Q20358

Conserved Domains (3) summary

cd00051
Location:96 → 158

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:24 → 84

EF-hand_7; EF-hand domain pair

cl08302
Location:25 → 85

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...