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    cth-2 Putative cystathionine gamma-lyase 2 [ Caenorhabditis elegans ]

    Gene ID: 174155, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cth-2
    Official Full Name
    Putative cystathionine gamma-lyase 2
    Primary source
    WormBase:WBGene00022856
    Locus tag
    CELE_ZK1127.10
    See related
    AllianceGenome:WB:WBGene00022856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cystathionine gamma-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in cysteine biosynthetic process via cystathionine and transsulfuration. Located in endoplasmic reticulum. Is expressed in anal depressor muscle; body wall musculature; hypodermis; and reproductive system. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cth-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (7056184..7057960, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Phage tail protein Neighboring gene Protein BCCIP homolog Neighboring gene Uncharacterized protein Neighboring gene fatty Acid CoA Synthetase family Neighboring gene MutS protein homolog him-14 Neighboring gene Nanos-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegans. Qabazard B, et al. Antioxid Redox Signal, 2014 Jun 1. PMID 24093496, Free PMC Article
    2. Molybdenum cofactor transfer from bacteria to nematode mediates sulfite detoxification. Warnhoff K, et al. Nat Chem Biol, 2019 May. PMID 30911177, Free PMC Article
    3. FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans. Choi HS, et al. Nat Commun, 2023 Feb 2. PMID 36732543, Free PMC Article
    4. Caenorhabditis elegans in the study of SMN-interacting proteins: a role for SMI-1, an orthologue of human Gemin2 and the identification of novel components of the SMN complex. Burt EC, et al. Invert Neurosci, 2006 Dec. PMID 16964508
    5. ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1. Statzer C, et al. Nat Commun, 2022 Feb 18. PMID 35181679, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-cysteine desulfhydrase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-cystine L-cysteine-lyase (deaminating) IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbon-sulfur lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cystathionine gamma-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cystathionine gamma-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteine biosynthetic process via cystathionine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transsulfuration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transsulfuration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 

    General protein information

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    Preferred Names
    Putative cystathionine gamma-lyase 2
    NP_495449.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7056184..7057960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063048.8 → NP_495449.1  Putative cystathionine gamma-lyase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495449.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55216
      Conserved Domains (2) summary
      PRK09028
      Location:9 → 372
      PRK09028; cystathionine beta-lyase; Provisional
      pfam01053
      Location:8 → 372
      Cys_Met_Meta_PP; Cys/Met metabolizm PLP-dependent enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55216.1

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