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    aakg-2 CBS domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aakg-2
    Official Full Name
    CBS domain-containing protein
    Primary source
    WormBase:WBGene00020633
    Locus tag
    CELE_T20F7.6
    See related
    AllianceGenome:WB:WBGene00020633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; regulation of carbohydrate metabolic process; and regulation of carbon utilization. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG1 (protein kinase AMP-activated non-catalytic subunit gamma 1); PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2); and PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aakg-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (16866046..16869031, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene Kinase Neighboring gene C2H2-type domain-containing protein Neighboring gene Acyl-CoA synthetase family member 2, mitochondrial Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Allosteric regulation of C. elegans AMP-activated protein kinase. Scanlon DM, et al. MicroPubl Biol, 2022. PMID 35622498, Free PMC Article
    2. DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. Tullet JM, et al. PLoS Genet, 2014 Feb. PMID 24516399, Free PMC Article
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of carbon utilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CBS domain-containing protein
    NP_510725.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      16866046..16869031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078324.8 → NP_510725.1  CBS domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510725.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02168
      Conserved Domains (3) summary
      COG0517
      Location:153 → 272
      CBS; CBS domain [Signal transduction mechanisms]
      cd04618
      Location:57 → 201
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:228 → 350
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    Nucleotide Protein
    Heading Accession and Version

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