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    ptrg-1 Tyrosine-protein phosphatase 4 [ Caenorhabditis elegans ]

    Gene ID: 177898, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptrg-1
    Official Full Name
    Tyrosine-protein phosphatase 4
    Primary source
    WormBase:WBGene00010558
    Locus tag
    CELE_K04D7.4
    See related
    AllianceGenome:WB:WBGene00010558
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in neuron projection development and signal transduction. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ptrg-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    18
    Sequence:
    Chromosome: IV; NC_003282.8 (10183842..10194445, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Small ribosomal subunit protein RACK1 Neighboring gene Mitochondrial sorting homolog Neighboring gene putative 4-aminobutyrate aminotransferase, mitochondrial Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GON-4-like protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans. Li Q, et al. Elife, 2020 Nov 24. PMID 33228848, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tyrosine-protein phosphatase 4
    NP_001255470.1
    • Confirmed by transcript evidence
    NP_001255471.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10183842..10194445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268541.3 → NP_001255470.1  Tyrosine-protein phosphatase 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255470.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3YT39, P28192, Q21214
      Conserved Domains (5) summary
      smart00194
      Location:642 → 900
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:83 → 120
      IG_like; Immunoglobulin like
      cd00047
      Location:675 → 900
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:140 → 232
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00102
      Location:977 → 1128
      Y_phosphatase; Protein-tyrosine phosphatase

    2. NM_001268542.3 → NP_001255471.1  Tyrosine-protein phosphatase 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255471.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P28192
      Conserved Domains (5) summary
      smart00194
      Location:596 → 854
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:37 → 74
      IG_like; Immunoglobulin like
      cd00047
      Location:629 → 854
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:94 → 186
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00102
      Location:931 → 1082
      Y_phosphatase; Protein-tyrosine phosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28192.3

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