U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lex-1 Tat-binding homolog 7 [ Caenorhabditis elegans ]

    Gene ID: 178146, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lex-1
    Official Full Name
    Tat-binding homolog 7
    Primary source
    WormBase:WBGene00008682
    Locus tag
    CELE_F11A10.1
    See related
    AllianceGenome:WB:WBGene00008682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP hydrolysis activity; chromatin binding activity; and histone binding activity. Involved in regulation of heterochromatin formation. Predicted to be active in nucleus. Orthologous to human ATAD2 (ATPase family AAA domain containing 2) and ATAD2B (ATPase family AAA domain containing 2B). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See lex-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (12079473..12084362)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene GOLD domain-containing protein Neighboring gene Matrin-type domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The bromodomain protein LEX-1 acts with TAM-1 to modulate gene expression in C. elegans. Tseng RJ, et al. Mol Genet Genomics, 2007 Nov. PMID 17618463
    2. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    3. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    4. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LEX-1 and TAM-1 function together to influence chromatin structure and to promote expression from repetitive sequences
      Title: The bromodomain protein LEX-1 acts with TAM-1 to modulate gene expression in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Tat-binding homolog 7
    NP_001122768.1
    • Confirmed by transcript evidence
    NP_502289.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12079473..12084362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069888.9 → NP_502289.2  Tat-binding homolog 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502289.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7LPG7, A7LPG8, P54816, Q21337, Q3YFF5
      Conserved Domains (3) summary
      cd05528
      Location:916 → 1027
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:424 → 565
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:428 → 563
      AAA; ATPase family associated with various cellular activities (AAA)

    2. NM_001129296.4 → NP_001122768.1  Tat-binding homolog 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122768.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54816
      Conserved Domains (3) summary
      cd05528
      Location:914 → 1025
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:422 → 563
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:426 → 561
      AAA; ATPase family associated with various cellular activities (AAA)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54816.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools