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    pho-6 Lysosomal acid phosphatase [ Caenorhabditis elegans ]

    Gene ID: 186114, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pho-6
    Official Full Name
    Lysosomal acid phosphatase
    Primary source
    WormBase:WBGene00018696
    Locus tag
    CELE_F52E1.8
    See related
    AllianceGenome:WB:WBGene00018696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatase activity. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J and prostate cancer. Orthologous to human ACP2 (acid phosphatase 2, lysosomal); ACP3 (acid phosphatase 3); and ACP4 (acid phosphatase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pho-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (8392256..8394457, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Chondroitin proteoglycan 3 Neighboring gene pseudo Neighboring gene ZP domain-containing protein Neighboring gene SHSP domain-containing protein Neighboring gene Guanylate cyclase;Receptor-type guanylate cyclase gcy-7 Neighboring gene TPX2 domain-containing protein Neighboring gene Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Lysosomal acid phosphatase
    NP_505167.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8392256..8394457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072766.4 → NP_505167.2  Lysosomal acid phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505167.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20662
      Conserved Domains (1) summary
      cl11399
      Location:19 → 314
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein
    Heading Accession and Version

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